8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol

Base Information

Chemical Name:8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol
CAS No.:204193-43-1
Molecular Formula:C15H20O4
Molecular Weight:264.321
Hs Code.:
DSSTox Substance ID:DTXSID00596019
Wikidata:Q82491144

Synonyms:8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol;204193-43-1;SCHEMBL744812;DTXSID00596019;ZLOYNHJYVCJDOJ-UHFFFAOYSA-N;DB-213422;8-(2-Hydroxymethyl-phenyl)-1,4-dioxa-spiro[4.5]decan-8-ol

Suppliers and Price of 8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:264.13615911
Heavy Atom Count:19
Complexity:301

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCC1(C3=CC=CC=C3CO)O)OCCO2

Technology Process of 8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol

There total 3 articles about 8-[2-(Hydroxymethyl)phenyl]-1,4-dioxaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 18982-54-2
o-bromobenzyl alcohol

: 204193-43-1
8-(2-(hydroxymethyl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: o-bromobenzyl alcohol; With n-butyllithium; In tetrahydrofuran; at -60 - -20 ℃; for 2.25h;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; at -60 - 20 ℃; for 18h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 25.0%

: 83365-44-0
1,7,10-trioxadispiro[2.2.4⁶.2³]dodecane

: 95-56-7
2-hydroxybromobenzene

: 204193-43-1
8-(2-(hydroxymethyl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: 1,7,10-trioxadispiro[2.2.4⁶.2³]dodecane; 2-hydroxybromobenzene; In toluene; for 0.0833333h;

With pyridine; for 18h; Heating / reflux;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 204193-43-1
8-(2-(hydroxymethyl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 8 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: -78 - 20 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/acs.orglett.1c04237