ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

Base Information

Chemical Name:ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate
CAS No.:207279-36-5
Molecular Formula:C12H13ClO2
Molecular Weight:224.687
Hs Code.:
DSSTox Substance ID:DTXSID90427525
Nikkaji Number:J457.995J
Wikidata:Q82240176

Synonyms:207279-36-5;ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate;Cyclopropanecarboxylic acid, 2-(4-chlorophenyl)-, ethyl ester, (1R,2R)-;Ethyl (1R,2R)-2-(4-Chlorophenyl)cyclopropanecarboxylate;ZINC02732104;SCHEMBL15056188;DTXSID90427525;AC9064;(+/-)-trans-ethyl 2-(4-chlorophenyl)cyclopropane-1-carboxylate;(1R)-1beta-(Ethoxycarbonyl)-2alpha-(4-chlorophenyl)cyclopropane

Suppliers and Price of ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:224.0604073
Heavy Atom Count:15
Complexity:234

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CC1C2=CC=C(C=C2)Cl
Isomeric SMILES:CCOC(=O)[C@@H]1C[C@H]1C2=CC=C(C=C2)Cl

Technology Process of ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

There total 8 articles about ethyl (1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.7%

: 623-73-4
diazoacetic acid ethyl ester

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 345905-96-6
ethyl trans-2-(4-chlorophenyl)cyclopropane-1-carboxylate

: 207279-36-5
(1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid ethyl ester

Guidance literature:: With sodium dithionite; c-type cytochrome maquette, C₄₅; In ethanol; at 5 - 25 ℃; for 2h; pH=8.6; stereoselective reaction; Catalytic behavior; Glovebox; Inert atmosphere; Enzymatic reaction;
DOI:10.1073/pnas.1915054117

Reference yield:

: 623-73-4
diazoacetic acid ethyl ester

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 345905-96-6
ethyl trans-2-(4-chlorophenyl)cyclopropane-1-carboxylate

: 395683-40-6
ethyl (1S,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

: 395683-39-3
ethyl (1R,2S)-2-(4-chlorophenyl)cyclopropane-1-carboxylate

: 207279-36-5
(1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid ethyl ester

Guidance literature:: With copper(I) triflate; copper(I)-chiral bipyridine complex C₂₂H₃₂ClCuN₂O₂; In chloroform; for 20h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1039/a706754b

Reference yield:

: 623-73-4
diazoacetic acid ethyl ester

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 207279-36-5
(1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid ethyl ester

: ethyl 2‐(4‐chlorophenyl)cyclopropane‐1‐carboxylate

Guidance literature:: With copper(I) trifluoromethanesolfonate toluene complex; C₄₄H₃₂N₂; In dichloromethane; at 25 ℃; for 5.5h; Overall yield = 94 %; stereoselective reaction; Schlenk technique;
DOI:10.1002/cjoc.201900141