6H-Purin-6-one, 2-aMino-1,7-dihydro-7-(phenylMethyl)- (hydrochloride)(1:1)

Base Information

• Chemical Name: 6H-Purin-6-one, 2-aMino-1,7-dihydro-7-(phenylMethyl)- (hydrochloride)(1:1)
• CAS No.: 20755-15-1
• Molecular Formula: C12H11N5O.ClH
• Molecular Weight: 277.713
• Mol file: 20755-15-1.mol

Synonyms:hydrochloride;2-Amino-7-benzyl-1,7-dihydro-purin-6-one;7-benzylguanine hydrochloride;6H-Purin-6-one, 2-amino-1,7-dihydro-7-(phenylmethyl)- (hydrochloride)(1:1);N7-Benzylguanine hydrochloride;2-amino-7-benzyl-1,7-dihydropurin-6-one hydrochloride;

Chemical Property of 6H-Purin-6-one, 2-aMino-1,7-dihydro-7-(phenylMethyl)- (hydrochloride)(1:1)

Chemical Property:

• PSA: 89.59000
• LogP: 2.13330

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6H-Purin-6-one, 2-aMino-1,7-dihydro-7-(phenylMethyl)- (hydrochloride)(1:1)

There total 3 articles about 6H-Purin-6-one, 2-aMino-1,7-dihydro-7-(phenylMethyl)- (hydrochloride)(1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl bromide (100-39-0) + G (118-00-3) → 2-amino-7-benzyl-6,7-dihydro-1H-purin-6-one hydrochloride (20755-15-1)

Guidance literature:

benzyl bromide; G; In N,N-dimethyl acetamide; at 60 ℃; for 24h;

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1081/SCC-200030585

Reference yield: 86.69%

benzyl bromide (100-39-0) + 2-amino-9-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one (26578-09-6) → 2-amino-7-benzyl-6,7-dihydro-1H-purin-6-one hydrochloride (20755-15-1)

Guidance literature:

benzyl bromide; 2-amino-9-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one; In dimethyl sulfoxide; at 20 ℃; for 4h;

With hydrogenchloride; water; In dimethyl sulfoxide; at 20 ℃; for 1h;

With methanol; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

benzyl bromide (100-39-0) + guanosine (118-00-3) → 2-amino-7-benzyl-6,7-dihydro-1H-purin-6-one hydrochloride (20755-15-1)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) DMSO, RT, 4 h, 2.) 30 min;

upstream raw materials:

benzyl bromide

guanosine

G

2-amino-9-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

Downstream raw materials:

7-benzyl-N²-isobutyrylguanine

theophiline-d6

1,3-dimethyl-7-benzylxanthine-d6

diethyl 7-benzylxanthine-1,3-diacetate