Quinazoline, 5,6,7,8-tetrahydro-2,4-diphenyl-

Base Information

• Chemical Name: Quinazoline, 5,6,7,8-tetrahydro-2,4-diphenyl-
• CAS No.: 20954-93-2
• Molecular Formula: C20H18N2
• Molecular Weight: 286.376
• Mol file: 20954-93-2.mol

Synonyms:

Chemical Property of Quinazoline, 5,6,7,8-tetrahydro-2,4-diphenyl-

Chemical Property:

• Melting Point: 122-123 °C
• Boiling Point: 404.5±45.0 °C(Predicted)
• PKA: 2.14±0.20(Predicted)
• Density: 1.130±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2,4-Diphenyl-5,6,7,8-tetrahydroquinazoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinazoline, 5,6,7,8-tetrahydro-2,4-diphenyl-

There total 14 articles about Quinazoline, 5,6,7,8-tetrahydro-2,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,4-diphenyl-5,6-tetramethylene-3-azapyrylium hexachloroantimonate(V) → 2,4-Diphenyl-5,6,7,8-tetrahydrobenzopyrimidine (20954-93-2)

Guidance literature:

With ammonium hydroxide; In diethyl ether; for 2h; Ambient temperature;

Reference yield: 87.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + benzonitrile (100-47-0) → 2,4-Diphenyl-5,6,7,8-tetrahydrobenzopyrimidine (20954-93-2)

Guidance literature:

With trifluoromethylsulfonic anhydride; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo00031a062

Reference yield: 77.0%

(2-bromocyclohex-1-en-1-yl)(phenyl)methanone (1001386-09-9) + benzamidine monohydrochloride (1670-14-0) → 2,4-Diphenyl-5,6,7,8-tetrahydrobenzopyrimidine (20954-93-2)

Guidance literature:

With potassium phosphate; copper; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

DOI:10.1055/s-0034-1380410

upstream raw materials:

cyclohexanone

benzonitrile

1-chlorocyclohexene

(2-bromocyclohex-1-en-1-yl)(phenyl)methanone