Benzenamine, 2-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-

Base Information

• Chemical Name: Benzenamine, 2-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-
• CAS No.: 209850-75-9
• Molecular Formula: C16H16N2O
• Molecular Weight: 252.316

Synonyms:(S)-2-(4-benzyl-4,5-dihydrooxazol-2-yl)aniline;2-((S)-4-Benzyl-4,5-dihydro-oxazol-2-yl)-phenylamine;2-(4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl)aniline;(4S)-benzyl-2-(2-aminophenyl)-oxazoline;

Chemical Property of Benzenamine, 2-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-

Chemical Property:

• Melting Point: 58 - 60 °C
• PSA: 47.61000
• LogP: 2.67370

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of Benzenamine, 2-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-

There total 9 articles about Benzenamine, 2-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-iodophenylamine (615-43-0) + (4S)-4-benzyl-4,5-dihydro-1,3-oxazole (75866-71-6) → 2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]aniline (209850-75-9)

Guidance literature:

With palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03041

Reference yield: 84.0%

N-[(1S)-1-benzyl-2-hydroxyethyl]-2-aminobenzamide (208175-33-1) → 2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]aniline (209850-75-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jo0262558

Reference yield: 76.0%

L-Phenylalaninol (3182-95-4) + anthranilic acid nitrile (1885-29-6) → 2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]aniline (209850-75-9)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; for 2h; Heating;

DOI:10.1021/ja016839b

upstream raw materials:

2-Amino-N-((S)-1-chloromethyl-2-phenyl-ethyl)-benzamide

isatoic anhydride

L-Phenylalaninol

N-[(1S)-1-benzyl-2-hydroxyethyl]-2-aminobenzamide

Downstream raw materials:

{2-[(4S)-4-benzyl-4,5-dihydrooxazol-2-yl]phenyl}(thiophene-2-carbonitrile)amine

2-[(S)-4-benzyl-4,5-dihydrooxazol-2-yl]-N-{2-[(S)-4-tert-butyl-4,5-dihydrothiazol-2-yl]phenyl}benzenamine

2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]anilino-3,5-bis(trifluoromethyl)anilinomethanethione

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