1-(4-Bromo-3-methylphenyl)propan-1-one

Base Information

• Chemical Name: 1-(4-Bromo-3-methylphenyl)propan-1-one
• CAS No.: 210228-01-6
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.101
• Hs Code.: 2914700090
• Mol file: 210228-01-6.mol

Synonyms:1-(4-bromo-3-methylphenyl)-1-propanone;1-(4-Brom-3-methyl-phenyl)-propan-1-on;1-(4-Bromo-3-methyl phenyl) propan-1-one;1-(4-bromo-3-methylphenyl)propane-1-one;

Chemical Property of 1-(4-Bromo-3-methylphenyl)propan-1-one

Chemical Property:

• PSA: 17.07000
• LogP: 3.35020
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

1-(4-Bromo-3-methylphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Bromo-3-methylphenyl)propan-1-one

There total 6 articles about 1-(4-Bromo-3-methylphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-bromo-3-methylbenzoic acid (7697-28-1) + ethylmagnesium bromide (925-90-6) → 1-(4-Bromo-3-methyl phenyl)-propan-1-one (210228-01-6)

Guidance literature:

4-bromo-3-methylbenzoic acid; With oxalyl dichloride; triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; at 0 ℃; for 0.5h;

With N,O-dimethylhydroxylamine*hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; for 14h;

ethylmagnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; for 18h;

Reference yield:

4-bromo-3-methylbenzonirtile (41963-20-6) + ethylmagnesium bromide (925-90-6) → 1-(4-Bromo-3-methyl phenyl)-propan-1-one (210228-01-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

4-bromo-3-methylbenzoic acid (7697-28-1) → 1-(4-Bromo-3-methyl phenyl)-propan-1-one (210228-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HOBt; EDC; DIEA / CH₂Cl₂

2: tetrahydrofuran / 0 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2003.08.056

upstream raw materials:

2-methylphenyl bromide

propionyl chloride

4-bromo-3-methylbenzoic acid

ethylmagnesium bromide

Downstream raw materials:

4-(4-bromo-3-methyl-phenyl)-3-methyl-4-oxo-butyric acid methyl ester

4-[4-(2-benzyl-3-oxo-cyclohex-1-enylamino)-3-methyl-phenyl]-3-methyl-4-oxo-butyric acid methyl ester

2-bromo-4'-bromo-5'-methylpropiophenone

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