Propionyl chloride

Base Information

• Chemical Name: Propionyl chloride
• CAS No.: 79-03-8
• Molecular Formula: C3H5ClO
• Molecular Weight: 92.5251
• Hs Code.: 2915.90
• European Community (EC) Number: 201-170-0
• NSC Number: 83547
• UN Number: 1815
• UNII: MB6VL5OMB9
• DSSTox Substance ID: DTXSID4058819
• Nikkaji Number: J4.227G
• Wikipedia: Propionyl_chloride
• Wikidata: Q13534584
• Mol file: 79-03-8.mol

Synonyms:propanoyl chloride;propionyl chloride

Chemical Property of Propionyl chloride

Chemical Property:

• Appearance/Colour: colorless liquid with a pungent odor
• Vapor Pressure: 105mmHg at 25°C
• Melting Point: -94 °C
• Refractive Index: 1.4302
• Boiling Point: 75.5 °C at 760 mmHg
• Flash Point: 11.7 °C
• PSA: 17.07000
• Density: 1.068 g/cm³
• LogP: 1.16180
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Water Solubility.: REACTS
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 92.0028925
• Heavy Atom Count: 5
• Complexity: 42.2
• Transport DOT Label: Flammable Liquid Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Propionyl Chloride >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C
• Hazard Codes: F,C
• Statements: 11-14-34-20/22
• Safety Statements: 9-16-26-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Acid Halides
• Canonical SMILES: CCC(=O)Cl
• Uses: Propionyl chloride is used as an intermediate in the production of agrochemicals and pharmaceuticals. It serves as an intermediate for dyes, textile auxiliaries and peroxide compounds. It acts as a crop protecting agent.

Technology Process of Propionyl chloride

There total 20 articles about Propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

propionic acid (802294-64-0,79-09-4) → propionyl chloride (79-03-8)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 70 - 75 ℃;

Reference yield: 89.0%

→ propionyl chloride (79-03-8)

Guidance literature:

Reference yield: 57.9%

propionic acid (802294-64-0,79-09-4) → propionyl chloride (79-03-8) + propionic acid anhydride (123-62-6)

Guidance literature:

With phosphorus trichloride; at 40 - 50 ℃; 4-5h;

DOI:10.1007/BF00960670

upstream raw materials:

benzoyl chloride

propionic acid

3,4-dichloro-(E)-3-hexene

trimethylsilyl propionate

Downstream raw materials:

1-chlorobutan-2-one

2-propionylfuran

1-thiophen-2-yl-propan-1-one

1-(5-methylthiophen-2-yl)propan-1-one

Refernces

• 1、 Zhang, Xueguo,Wang, Peigen,Zhu, Liangwei,Chen, Baohua. "Rhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C–H activation". supporting information. p. 695 - 699. Retrieved 2020/06/28.
• 2、 Nasier, Abudulajiang,Chang, Xihao,Guo, Chang. "Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines". . p. 16068 - 16076. Retrieved 2021/09/18.