2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-

Base Information

Chemical Name:2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-
CAS No.:212554-36-4
Molecular Formula:C8H12O2
Molecular Weight:140.182
Hs Code.:
DSSTox Substance ID:DTXSID60462180
Nikkaji Number:J982.916D

Synonyms:212554-36-4;2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-;DTXSID60462180

Suppliers and Price of 2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:140.083729621
Heavy Atom Count:10
Complexity:170

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CC=C(C(=O)C1)CO

Technology Process of 2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl-

There total 1 articles about 2-Cyclohexen-1-one, 2-(hydroxymethyl)-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 7214-50-8
5-methylcyclohex-2-en-1-one

: 212554-36-4
2-hydroxymethyl-5-methyl-2-cyclohexen-1-one

Guidance literature:: With dmap; In tetrahydrofuran; water; at 25 ℃; for 72h;
DOI:10.1016/S0040-4039(98)01206-4

Reference yield: 82.0%

: 108-24-7
acetic anhydride

: 212554-36-4
2-hydroxymethyl-5-methyl-2-cyclohexen-1-one

: 606146-61-6
2-acetoxymethyl-5-methyl-2-cyclohexenone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(03)01516-8

Reference yield:

: 212554-36-4
2-hydroxymethyl-5-methyl-2-cyclohexen-1-one

: (1RS,3SR,5RS)-3-((2SR)-6-tert-butyloxycarbonylamino-2-hydroxy-3-hexynyl)-5-methyl-2-methylenecyclohexanol

Guidance literature:: Multi-step reaction with 8 steps

1: 81.5 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 1.5 h / 0 °C

3: 74.2 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

4: diisopropylamine; n-BuLi; 4-hydroxymethylphenoxyacetic acid / TBSCl / tetrahydrofuran / 72 h / -78 - 20 °C

5: 18.8 g / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

6: 98.1 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 20 °C

7: 82 percent / n-BuLi; 4-hydroxymethylphenoxyacetic acid / tetrahydrofuran / 1 h / 0 °C

8: 42.7 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Heating

With 2,6-dimethylpyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; cerium(III) chloride; tetrabutyl ammonium fluoride; Dess-Martin periodane; [4-(hydroxymethyl)phenoxy]acetic acid; triethylamine; diisopropylamine; tert-butyldimethylsilyl chloride; In tetrahydrofuran; methanol; dichloromethane; 2: Luche reduction;
DOI:10.1016/j.tet.2005.02.044