2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-

Base Information

Chemical Name:2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-
CAS No.:212890-35-2
Molecular Formula:C15H18F2O3
Molecular Weight:284.303
Hs Code.:
DSSTox Substance ID:DTXSID40709787
Mol file:212890-35-2.mol

Synonyms:212890-35-2;2-[(1R)-1-[2-(2,4-DIFLUOROPHENYL)OXIRAN-2-YL]ETHOXY]OXANE;2-{(1R)-1-[2-(2,4-Difluorophenyl)oxiran-2-yl]ethoxy}oxane;2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-;SCHEMBL7680319;DTXSID40709787;PWBIMUAZFIPFKO-SFNBMPIDSA-N;2-(2,4-Difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yl)oxyethyl]oxirane;2-(2,4-difluorophenyl)-2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]oxirane;2-[(1R)-1-(3,4,5,6 -tetrahydro-2H-pyran-2-yloxy)ethyl]-2-(2,4-difluorophenyl)oxirane;2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane;2-[(1R)-1-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)ethyl]-2-(2,4-difluorophenyl)oxirane

Suppliers and Price of 2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:284.12240076
Heavy Atom Count:20
Complexity:341

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1(CO1)C2=C(C=C(C=C2)F)F)OC3CCCCO3
Isomeric SMILES:C[C@H](C1(CO1)C2=C(C=C(C=C2)F)F)OC3CCCCO3

Technology Process of 2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-

There total 8 articles about 2H-Pyran, 2-[(1R)-1-[2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: trimethylsulfoxonium iodide

: 127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0
(2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 212890-35-2
2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 0 - 20 ℃; for 1h;

(2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone; In dimethyl sulfoxide; at 20 ℃; for 4h;

Reference yield:

: 1774-47-6
trimethylsulfoxonium iodide

: 127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0
(2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 212890-35-2
2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 2 h;
DOI:10.1248/cpb.41.1035

Reference yield:

: 135270-08-5
4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

: 212890-35-2
2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran

2: NaH; DMSO

With sodium hydride; dimethyl sulfoxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.03.074