Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester

Base Information

• Chemical Name: Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester
• CAS No.: 2129-79-5
• Molecular Formula: C15H17O2P
• Molecular Weight: 260.273
• DSSTox Substance ID: DTXSID70392808
• Nikkaji Number: J2.339.793E
• Mol file: 2129-79-5.mol

Synonyms:Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester;2129-79-5;[ethoxy(phenyl)phosphoryl]methylbenzene;SCHEMBL7916451;DTXSID70392808;Benzylphenylphosphinic acid ethyl ester

Chemical Property of Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 260.09661678
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOP(=O)(CC1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester

There total 8 articles about Phosphinic acid, phenyl(phenylmethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate (260783-80-0) + ethyl Phenylphosphinate (172487-18-2,2511-09-3) → Benzylphenylphosphinsaeureethylester (2129-79-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2020.131020

Reference yield: 90.0%

(±)-benzyl(phenyl)phosphinic acid (7282-98-6) + Triethyl orthoacetate (78-39-7) → Benzylphenylphosphinsaeureethylester (2129-79-5)

Guidance literature:

In various solvent(s); at 80 ℃; for 2.5h;

DOI:10.1016/j.tet.2005.09.147

Reference yield: 80.0%

benzaldehyde p-toluenesulfonylhydrazone (1666-17-7) + ethyl Phenylphosphinate (172487-18-2,2511-09-3) → Benzylphenylphosphinsaeureethylester (2129-79-5)

Guidance literature:

With copper(l) iodide; caesium carbonate; In 1,2-dimethoxyethane; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201200295

upstream raw materials:

diethyl phenylphosphonite

benzyl chloride

(±)-benzyl(phenyl)phosphinic acid

Triethyl orthoacetate

Downstream raw materials:

(±)-benzyl(phenyl)phosphinic acid

N--O-trimethylsilylhydroxylamine

N-hydroxylamine

α-methylbenzyl(phenyl)phosphinic chloride

Refernces

• 1、 Chen, Tieqiao,Huang, Tianzeng,Liu, Long,Wang, Wenqi,Wang, Yuan,Xu, Hanshuang,Xu, Kaiqiang. "Palladium-catalyzed phosphorylation of benzyl ammonium triflates with P(O)H compounds". . . Retrieved 2020/03/03.
• 2、 Miao, Wenjun,Gao, Yuzhen,Li, Xueqin,Gao, Yuxing,Tang, Guo,Zhao, Yufen. "Copper-catalyzed synthesis of alkylphosphonates from H-phosphonates and N-tosylhydrazones". . p. 2659 - 2664. Retrieved 2013/01/15.