2-(Trimethylsilylethynyl)phenyl isocyanide

Base Information

Chemical Name:2-(Trimethylsilylethynyl)phenyl isocyanide
CAS No.:213334-93-1
Molecular Formula:C12H13NSi
Molecular Weight:199.327
Hs Code.:
DSSTox Substance ID:DTXSID901243862
Nikkaji Number:J1.160.888D

Synonyms:2-(Trimethylsilylethynyl)phenyl isocyanide;DTXSID901243862;1-Isocyano-2-[2-(trimethylsilyl)ethynyl]benzene;213334-93-1

Suppliers and Price of 2-(Trimethylsilylethynyl)phenyl isocyanide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(Trimethylsilylethynyl)phenyl isocyanide

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:199.081725953
Heavy Atom Count:14
Complexity:303

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)C#CC1=CC=CC=C1[N+]#[C-]

Technology Process of 2-(Trimethylsilylethynyl)phenyl isocyanide

There total 7 articles about 2-(Trimethylsilylethynyl)phenyl isocyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 112671-40-6
2-(trimethylsilylethynyl)formanilide

: 213334-93-1
o-((trimethylsilyl)ethynyl)phenyl isocyanide

Guidance literature:: With diisopropylamine; trichlorophosphate; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jo000831n

Reference yield:

: 615-43-0
2-iodophenylamine

: 213334-93-1
o-((trimethylsilyl)ethynyl)phenyl isocyanide

Guidance literature:: Multi-step reaction with 3 steps

1: diethylamine / tetrakis(triphenylphosphine)palladium⁽⁰⁾; copper(I) iodide / dimethylformamide / 6 h / 20 °C

2: tetrahydrofuran / 12 h / 0 °C

3: 2.28 g / triethylamine; phosphorous oxychloride / tetrahydrofuran / 2 h / 0 °C

With diethylamine; triethylamine; trichlorophosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira-Hagihara coupling;
DOI:10.1021/ol991133w

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 213334-93-1
o-((trimethylsilyl)ethynyl)phenyl isocyanide

Guidance literature:: Multi-step reaction with 3 steps

1: CuI; Et₃N / Pd(PPh₃)4 / dimethylformamide / 20 °C

2: tetrahydrofuran / 20 °C

3: Et₃N; POCl₃ / tetrahydrofuran / 0 °C

With copper(l) iodide; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja016355f