[(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid

Base Information

• Chemical Name: [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid
• CAS No.: 6488-68-2
• Molecular Formula: C₂₆H₃₂O₆
• Molecular Weight: 440.536
• Mol file: 6488-68-2.mol

Synonyms:

Chemical Property of [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid

There total 2 articles about [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-deacetoxy-7-oxogedunin (13072-74-7) → [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid (6488-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CrCl₂, aq. HCl

2: aq. KOH

With chromium dichloride; hydrogenchloride; potassium hydroxide;

DOI:10.1039/j39670000171

Reference yield:

→ [2-((1R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid (6488-68-2)

Guidance literature:

Anhydro-angolesinsaeure (Va), H2 an PtO2 in Methanol;

DOI:10.1039/j39660000944

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid (6488-68-2) → [(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid methyl ester (14699-30-0)

Guidance literature:

DOI:10.1039/j39670000171

upstream raw materials:

7-deacetoxy-7-oxogedunin

Downstream raw materials:

[(1R,2R)-2-((1R,6R,8aR)-1-Furan-3-yl-5,8a-dimethyl-3-oxo-3,4,6,7,8,8a-hexahydro-1H-isochromen-6-yl)-2,6,6-trimethyl-5-oxo-cyclohex-3-enyl]-acetic acid methyl ester