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13072-74-7

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  • Oxireno[c]phenanthro[1,2-d]pyran-3,5,8(3aH,4bH,7H)-trione,1-(3-furanyl)-1,6,6a,10a,10b,11,12,12a-octahydro-4b,7,7,10a,12a-pentamethyl-,(1S,3aS,4aR,4bR,6aR,10aS,10bR,12aS)-

    Cas No: 13072-74-7

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  • Oxireno[c]phenanthro[1,2-d]pyran-3,5,8(3aH,4bH,7H)-trione,1-(3-furanyl)-1,6,6a,10a,10b,11,12,12a-octahydro-4b,7,7,10a,12a-pentamethyl-,(1S,3aS,4aR,4bR,6aR,10aS,10bR,12aS)- cas 13072-74-7

    Cas No: 13072-74-7

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13072-74-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13072-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,7 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 13072-74:
(7*1)+(6*3)+(5*0)+(4*7)+(3*2)+(2*7)+(1*4)=77
77 % 10 = 7
So 13072-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H30O6/c1-22(2)16-12-18(28)25(5)15(23(16,3)9-7-17(22)27)6-10-24(4)19(14-8-11-30-13-14)31-21(29)20-26(24,25)32-20/h7-9,11,13,15-16,19-20H,6,10,12H2,1-5H3

13072-74-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Oxodeacetoxydihydro-.α.-gedunol

1.2 Other means of identification

Product number -
Other names 7-Oxo-7-deacetoxygedunin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:13072-74-7 SDS

13072-74-7Upstream product

13072-74-7Related news

Regular ArticleInterference of the Natural Product 7-Oxo-7-deacetoxygedunin (cas 13072-74-7) with CF0of H+-ATPase of Spinach Chloroplasts☆☆☆★★★09/10/2019

7-Oxo-7-deacetoxygedunin, a limonoid isolated fromGuarea grandiflora(Meliaceae) has been found to act as an inhibitor of photophosphorylation in spinach thylakoids. ATP synthesis and phosphorylating electron flows were inhibited by 88 and 83%, respectively, at 300 μM of 7-oxo-7-deacetoxygedunin...detailed

13072-74-7Relevant articles and documents

Gedunin, a novel Hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationships

Brandt, Gary E. L.,Schmidt, Matthew D.,Prisinzano, Thomas E.,Blagg, Brian S. J.

experimental part, p. 6495 - 6502 (2009/10/17)

Gedunin (1), a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors. The mechanism of action by which gedunin induces client protein degradation remains undetermined, however, prior studies have demonstrated that it does not bind competitively versus ATP. In an effort to further probe the mechanism of action, 19 semisynthetic derivatives of gedunin were prepared and their antiproliferative activity against MCF-7 and SkBr3 breast cancer cells determined. Although no compound was found to exhibit antiproliferative activity more effective than the natural product, functionalities critical for antiproliferative activity have been identified.

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