3H-1,2,4-Triazol-3-one, 4-(4-bromophenyl)-2-[(1S,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1- methylpropyl]-2,4-dihydro-

Base Information

• Chemical Name: 3H-1,2,4-Triazol-3-one, 4-(4-bromophenyl)-2-[(1S,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1- methylpropyl]-2,4-dihydro-
• CAS No.: 214117-52-9
• Molecular Formula: C18H28BrN3O2Si
• Molecular Weight: 426.429
• Mol file: 214117-52-9.mol

Synonyms:

Chemical Property of 3H-1,2,4-Triazol-3-one, 4-(4-bromophenyl)-2-[(1S,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1- methylpropyl]-2,4-dihydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-1,2,4-Triazol-3-one, 4-(4-bromophenyl)-2-[(1S,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1- methylpropyl]-2,4-dihydro-

There total 4 articles about 3H-1,2,4-Triazol-3-one, 4-(4-bromophenyl)-2-[(1S,2R)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1- methylpropyl]-2,4-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2,4-dihydro-4-(4-bromophenyl)-2-[(2S,3R)-(3-hydroxy-2-butyl)]-3H-1,2,4-triazol-3-one (648416-96-0) → 2,4-dihydro-4-(4-bromophenyl)-2-[(2S,3R)-[3-(1,1-dimethylethyl)dimethylsiloxy]-but-2-yl]-3H-1,2,4-triazol-3-one (214117-52-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.tetasy.2003.01.001

Reference yield:

4-bromophenyl isocyanate (2493-02-9) → 2,4-dihydro-4-(4-bromophenyl)-2-[(2S,3R)-[3-(1,1-dimethylethyl)dimethylsiloxy]-but-2-yl]-3H-1,2,4-triazol-3-one (214117-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: butan-1-ol / 0 - 20 °C

1.2: 49 percent / KOH / butan-1-ol / 3 h / Heating

2.1: potassium carbonate; tris(3,6-dioxaheptyl)amine / acetonitrile / 16 h / 40 °C

2.2: 79 percent / HBr / 0.75 h / 50 °C

3.1: 99 percent / imidazole / dimethylformamide / 48 h / 20 °C

With 1H-imidazole; Tris(3,6-dioxaheptyl)amine; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

DOI:10.1016/j.tetasy.2003.01.001

Reference yield:

2,4-dihydro-4-(4-bromophenyl)-3H-1,2,4-triazol-3-one (214117-50-7) → 2,4-dihydro-4-(4-bromophenyl)-2-[(2S,3R)-[3-(1,1-dimethylethyl)dimethylsiloxy]-but-2-yl]-3H-1,2,4-triazol-3-one (214117-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; tris(3,6-dioxaheptyl)amine / acetonitrile / 16 h / 40 °C

1.2: 79 percent / HBr / 0.75 h / 50 °C

2.1: 99 percent / imidazole / dimethylformamide / 48 h / 20 °C

With 1H-imidazole; Tris(3,6-dioxaheptyl)amine; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetasy.2003.01.001

upstream raw materials:

tert-butyldimethylsilyl chloride

2,4-dihydro-4-(4-bromophenyl)-2-[(2S,3R)-(3-hydroxy-2-butyl)]-3H-1,2,4-triazol-3-one

4-bromophenyl isocyanate

2,4-dihydro-4-(4-bromophenyl)-3H-1,2,4-triazol-3-one

Downstream raw materials:

(2R,4S)-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(2S,3R)-3-[(1,1-dimethylethyl)dimethylsiloxy-2-butyl]]-3H-1,2,4-triazol-3-one

(2R,4S)-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(2S,3R)-(3-hydroxy-2-butyl)]-3H-1,2,4-triazol-3-one