(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid

Base Information

Chemical Name:(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid
CAS No.:214193-13-2
Molecular Formula:C6H9NO2
Molecular Weight:127.143
Hs Code.:
ChEMBL ID:CHEMBL3785412
DSSTox Substance ID:DTXSID10585530
Nikkaji Number:J2.095.818I
Mol file:214193-13-2.mol

Synonyms:214193-13-2;(1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID;(1S,3S,5S)-2-Azabicyclo-[3.1.0]hexane-3-carboxylic acid;97250-96-9;cis-4,5-methano-l-proline;SCHEMBL5066494;CHEMBL3785412;DTXSID10585530;AKOS006237682;AS-50582;CS-0057230;EN300-30421;P10629;EN300-1068400;A857998;(1S,3S,5S)-rel-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid;(1S,3S,5S)-rel-2-Azabicyclo[3.1.0]hexane-3-carboxylicacid;rac-(1R,3R,5R)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

Suppliers and Price of (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylicAcid
2.5mg
$ 65.00

Synthonix
(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylicacid 95+%
1g
$ 880.00

Synthonix
(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylicacid 95+%
10g
$ 5270.00

Synthonix
(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylicacid 95+%
5g
$ 3040.00

Matrix Scientific
(1S,3S,5S)-2-Azabicyclo-[3.1.0]hexane-3-carboxylicacid 95+%
1g
$ 1552.00

Crysdot
(1S,3S,5S)-2-Azabicyclo-[3.1.0]hexane-3-carboxylicacid 95+%
1g
$ 940.00

Chemenu
(1S,3S,5S)-2-Azabicyclo-[3.1.0]hexane-3-carboxylicacid 95%
1g
$ 886.00

American Custom Chemicals Corporation
(1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID 95.00%
5MG
$ 505.07

Total 12 raw suppliers

Chemical Property of (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid

Chemical Property:

PSA：49.33000
LogP:0.15020
XLogP3:-2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:127.063328530
Heavy Atom Count:9
Complexity:157

Purity/Quality:

97% ^*data from raw suppliers

(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2C1NC(C2)C(=O)O
Isomeric SMILES:C1[C@@H]2[C@H]1N[C@@H](C2)C(=O)O

Technology Process of (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid

There total 7 articles about (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214193-11-0
(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-formic acid ethyl ester

: 214193-13-2
cis-4,5-methano-L-proline

Guidance literature:: With lithium hydroxide; formic acid; Yield given. Multistep reaction; 1.) MeOH;
DOI:10.1016/S0960-894X(98)00377-1

Reference yield:

: A₂₂a

: 214193-13-2
cis-4,5-methano-L-proline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 44h;

Reference yield:

: 144978-35-8,144978-12-1,251924-83-1
(S)-ethyl N-tert-butoxycarbonylpyroglutamate

: 214193-13-2
cis-4,5-methano-L-proline

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / LiBEt₃H / tetrahydrofuran

2: PPTS

3: NH₄Cl / 150 °C / 20 - 100 Torr

4: 65 percent / Et₂Zn / 1,2-dichloro-ethane; hexane / a) 0 deg C, 30 min, b) RT, 6 h

5: DMAP, Et₃N / CH₂Cl₂

6: 1.) aq. LiOH, 2.) HCO₂H / 1.) MeOH

With dmap; lithium hydroxide; formic acid; diethylzinc; pyridinium p-toluenesulfonate; lithium triethylborohydride; ammonium chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(98)00377-1