1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate

Base Information

• Chemical Name: 1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate
• CAS No.: 214471-76-8
• Molecular Formula: C12H19N3O2
• DSSTox Substance ID: DTXSID501165983
• Mol file: 214471-76-8.mol

Synonyms:SCHEMBL13940974;DTXSID501165983;214471-76-8;1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate

Chemical Property of 1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 237.147726857
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1=CC=CC(=N1)CN

Technology Process of 1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate

There total 6 articles about 1,1-Dimethylethyl N-[[6-(aminomethyl)-2-pyridinyl]methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-azidomethyl-pyridin-2-ylmethyl)-carbamic acid tert-butyl ester (628308-55-4) → (6-aminomethyl-pyridin-2-ylmethyl)-carbamic acid tert-butyl ester (214471-76-8)

Guidance literature:

With hydrogen; nickel;

DOI:10.1016/S0968-0896(03)00216-5

Reference yield:

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → (6-aminomethyl-pyridin-2-ylmethyl)-carbamic acid tert-butyl ester (214471-76-8)

Guidance literature:

Multi-step reaction with 6 steps

1: SOCl₂

2: NaN₃; Na₂CO₂

3: H₂NNH₂

4: H₂ / Raney Ni

With thionyl chloride; sodium azide; hydrogen; sodium carbonate; hydrazine; nickel;

DOI:10.1016/S0968-0896(03)00216-5

Reference yield:

2,6-bis(chloromethyl)pyridine (3099-28-3) → (6-aminomethyl-pyridin-2-ylmethyl)-carbamic acid tert-butyl ester (214471-76-8)

Guidance literature:

Multi-step reaction with 5 steps

1: NaN₃; Na₂CO₂

2: H₂NNH₂

3: H₂ / Raney Ni

With sodium azide; hydrogen; sodium carbonate; hydrazine; nickel;

DOI:10.1016/S0968-0896(03)00216-5

upstream raw materials:

(6-azidomethyl-pyridin-2-ylmethyl)-carbamic acid tert-butyl ester

2.6-bis(hydroxymethyl)pyridine

2,6-bis(chloromethyl)pyridine

(2-aminomethyl)(6-azidomethyl)pyridine