m-PEG2-Azide

Base Information

• Chemical Name: m-PEG2-Azide
• CAS No.: 215181-61-6
• Molecular Formula: C5H11N3O2
• Molecular Weight: 145.161
• Mol file: 215181-61-6.mol

Synonyms:2-(2-methoxyethoxy)ethyl azide;1-azido-2-(2-methoxyethoxy)ethane;1-azido-2-(2-methoxy-ethoxy)-ethane;2-(2-methoxyethoxy)ethyl tosylate;

Chemical Property of m-PEG2-Azide

Chemical Property:

• PSA: 68.21000
• LogP: 0.41246
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Sparingly), Acetone (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Azido-2-(2-methoxyethoxy)ethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG2-azide is a PEG linker containing reactive azide group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Technology Process of m-PEG2-Azide

There total 5 articles about m-PEG2-Azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) → 1-(1-ethoxy-2-azido)-2-methoxyethane (215181-61-6,89485-61-0)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

DOI:10.1039/c3sm52061g

Reference yield: 87.3%

2-bromoethyl 2-methoxyethyl ether (54149-17-6,92450-98-1) → 1-(1-ethoxy-2-azido)-2-methoxyethane (215181-61-6,89485-61-0)

Guidance literature:

With sodium azide; In water; for 16h; Heating;

DOI:10.1002/anie.200454078

Reference yield: 87.3%

→ 1-(1-ethoxy-2-azido)-2-methoxyethane (215181-61-6,89485-61-0)

Guidance literature:

upstream raw materials:

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

2-bromoethyl 2-methoxyethyl ether

2-(2-methoxyethoxy)ethyl alcohol

methanesulfonic acid 2-(2-methoxyethoxy)ethyl ester

Downstream raw materials:

4-methoxy-benzaldehyde

C₁₉H₂₄N₄O₅S

C₂₀H₂₄N₂O₆S

C₁₃H₂₀N₂O₃

Refernces

• 1、 Chua, Giles B. H.,Roth, Peter J.,Duong, Hien T. T.,Davis, Thomas P.,Lowe, Andrew B.. "Synthesis and thermoresponsive solution properties of poly[oligo(ethylene glycol) (meth)acrylamide]s: Biocompatible PEG analogues". . p. 1362 - 1374. Retrieved 2012.
• 2、 Li, Po-Cheng,Lin, Yung-Chih,Chen, Ming,Kuo, Shiao-Wei. "Self-assembled structures from PEGylated polypeptide block copolymers synthesized using a combination of ATRP, ROP, and click chemistry". . p. 11257 - 11269. Retrieved 2013.