trans-1-Boc-3-cyano-4-hydroxypyrrolidine

Base Information

• Chemical Name: trans-1-Boc-3-cyano-4-hydroxypyrrolidine
• CAS No.: 215922-85-3
• Molecular Formula: C10H16N2O3
• Molecular Weight: 212.25
• Mol file: 215922-85-3.mol

Synonyms:

Chemical Property of trans-1-Boc-3-cyano-4-hydroxypyrrolidine

Chemical Property:

• Boiling Point: 361.4±42.0 °C(Predicted)
• PKA: 13.48±0.40(Predicted)
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

trans-1-Boc-3-cyano-4-hydroxypyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-Boc-3-cyano-4-hydroxypyrrolidine

There total 23 articles about trans-1-Boc-3-cyano-4-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester (175463-32-8) → tert-butyl 3-cyano-4-hydroxypyrrolidine-1-carboxylate (197143-33-2,215922-85-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.5h;

DOI:10.1021/jm970202e

Reference yield: 91.0%

(+/-)-1,1-dimethylethyl trans-3-cyano-4-[(trimethylsilyl)oxy]-1-pyrrolidinecarboxylate → (trans)-tert-butyl 3-cyano-4-hydroxypyrrolidine-1-carboxylate (215922-85-3)

Guidance literature:

With potassium carbonate; In methanol; for 0.166667h;

DOI:10.3891/acta.chem.scand.52-1214

Reference yield: 76.0%

C26H34N2O3Si → C10H16N2O3 (215922-85-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester

N-cyanoethyl glycine ethyl ester

di-tert-butyl dicarbonate

N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester

Downstream raw materials:

tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate

4-(tert-butoxycarbonyl)aminomethyl-1-(t-butoxycarbonyl)pyrrolidin-3-ol

(3S,4S)-3-cyano-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

(R,R)-3-hydroxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester