ethyl N-(tert-butoxycarbonyl)-N-(2-cyanoethyl)glycinate

Base Information

• Chemical Name: ethyl N-(tert-butoxycarbonyl)-N-(2-cyanoethyl)glycinate
• CAS No.: 266353-18-8
• Molecular Formula: C12H20N2O4
• Molecular Weight: 256.302
• Mol file: 266353-18-8.mol

Synonyms:N-BOC-N-(2-CYANOETHYL) GLYCINE ETHYL ESTER;N-tert-butoxycarbonyl-N-cyanoethyl glycine ethyl ester;

Chemical Property of ethyl N-(tert-butoxycarbonyl)-N-(2-cyanoethyl)glycinate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• PSA: 79.63000
• LogP: 1.70028

Purity/Quality:

98% HPLC ^*data from raw suppliers

Ethyl2-((tert-butoxycarbonyl)(2-cyanoethyl)amino)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl N-(tert-butoxycarbonyl)-N-(2-cyanoethyl)glycinate

There total 4 articles about ethyl N-(tert-butoxycarbonyl)-N-(2-cyanoethyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + glycine ethyl ester hydrochloride (623-33-6) + acrylonitrile (107-13-1,25014-41-9) → N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester (266353-18-8)

Guidance literature:

glycine ethyl ester hydrochloride; acrylonitrile; With sodium hydroxide; In methanol; at 55 - 60 ℃; for 8.5h;

di-tert-butyl dicarbonate; In methanol; at 20 ℃; for 1.5h;

Reference yield: 94.2%

di-tert-butyl dicarbonate (24424-99-5) → N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester (266353-18-8)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

N-cyanoethyl glycine ethyl ester (44981-94-4) + di-tert-butyl dicarbonate (24424-99-5) → N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester (266353-18-8)

Guidance literature:

In chloroform; for 17h; Ambient temperature;

DOI:10.1021/jm970202e

upstream raw materials:

N-cyanoethyl glycine ethyl ester

di-tert-butyl dicarbonate

glycine ethyl ester hydrochloride

acrylonitrile

Downstream raw materials:

5-((R)-2-methoxy-2-phenylacetyl)-3-[4-(4-methylpiperazin-1-yl)benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

danusertib

3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate

Refernces

• 1、 -. "Preparation method of zabofloxacin intermediate". Paragraph 0045-0068. . Retrieved 2018/10/27.
• 2、 -. "Gemifloxacin intermediate preparation method". Paragraph 0025. . Retrieved 2016/11/07.