6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine

Base Information

Chemical Name:6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine
CAS No.:216661-57-3
Molecular Formula:C17H13N3OS
Molecular Weight:307.376
Hs Code.:
UNII:FHX0K077F6
DSSTox Substance ID:DTXSID90416191
Nikkaji Number:J1.798.138B
Wikidata:Q27089132
Pharos Ligand ID:LS9STRVUCRQ5
ChEMBL ID:CHEMBL92461
Mol file:216661-57-3.mol

Synonyms:216661-57-3;KDR/Flk-1 Kinase Inhibitor IV;pyrazolo[1,5-a]pyrimidine 3g;Vegf 2 kinase inhibitor IV;VEGF Receptor 2 Kinase Inhibitor IV;FHX0K077F6;Pyrazolo[1,5-a]pyrimidine, 6-(4-methoxyphenyl)-3-(3-thienyl)-;VEGFR2 KINASE INHIBITOR IV;UNII-FHX0K077F6;CHEMBL92461;3-(3-Thienyl)-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine;6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine;Pyrazolo(1,5-a)pyrimidine, 6-(4-methoxyphenyl)-3-(3-thienyl)-;6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidine;3-(3-thienyl)-6-(4-methoxyphenyl)pyrazolo(1,5-A)pyrimidine;HMS3229O15;6-(4-methoxyphenyl)-3-thiophen-3-ylpyrazolo[1,5-a]pyrimidine;D09LKM;BDBM5432;GTPL6055;SCHEMBL3003967;CHEBI:93078;DTXSID90416191;HBWLNACPIFKNIP-UHFFFAOYSA-N;HSCI1_000335;CCG-206808;FT-0723196;J-014220;BRD-K61737877-001-01-6;Q27089132;3-(3-thienyl)-6-(4-methoxyphenyl) pyrazolo(1,5-a)pyrimidine

Suppliers and Price of 6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:307.07793322
Heavy Atom Count:22
Complexity:375

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CSC=C4)N=C2

Technology Process of 6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine

There total 8 articles about 6-(4-Methoxyphenyl)-3-(3-thienyl)-pyrazolo(1,5-a)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 216661-57-3
3-(thien-3-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine

Guidance literature:

Reference yield:

: 65192-28-1
2-(4-methoxyphenyl)malondialdehyde

: 162286-51-3
4-(thiophen-3-yl)-1H-pyrazol-5-amine

: 216661-57-3
3-(thien-3-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine

Guidance literature:: In ethanol; acetic acid; at 120 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.bmcl.2019.126813

Reference yield:

: 13781-53-8
(thiophen-3-yl)acetonitrile

: 216661-57-3
3-(thien-3-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / DMA / toluene / Heating

2: 65 percent / H₂NNH₂ / ethanol / Heating

3: AcOH / ethanol / Heating

With 2,4-dichlorophenoxyacetic acid dimethylamine; acetic acid; hydrazine; In ethanol; toluene;
DOI:10.1016/S0960-894X(02)00827-2