Synonyms:
There total 1 articles about 6-bromo-2-(3-fluoro-4-hydroxy-phenyl)-3-phenyl-quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield:
The research explores a novel method for synthesizing biheterocyclic compounds. The purpose of this study is to develop a direct and efficient route for the cross-coupling of tautomerizable heterocycles with unfunctionalized heteroarenes, aiming to create a variety of biologically active and functionally important biheterocyclic frameworks. The key chemicals used in this research include tautomerizable heterocycles such as 2-methyl-1H-pyridazine-3,6-dione, heteroarenes like 2-phenyl-1,3,4-oxadiazole, and catalysts such as Pd(OAc)2 and CuI. The methodology involves PyBroP-mediated activation of the heterocycles to form phosphonium salts, followed by Pd/Cu-catalyzed coupling reactions. The study concludes that this approach allows for the facile synthesis of both unsymmetrical and symmetrical biheterocyclic compounds, including diazine-azole and bidiazine units, using readily available substrates. This method provides a significant advancement in the synthesis of biheterocyclic compounds, offering a more direct and efficient route compared to traditional multi-step processes.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
