Chemical Property of Srpin340
Chemical Property:
- Boiling Point:395.9±42.0 °C(Predicted)
- PKA:11.09±0.70(Predicted)
- PSA：45.23000
- Density:1.306±0.06 g/cm3(Predicted)
- LogP:4.48100
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:3.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:3
- Exact Mass:349.14019669
- Heavy Atom Count:25
- Complexity:445
- Purity/Quality:
-
99%, *data from raw suppliers
SRPIN340 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3
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Description
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.
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Uses
SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.
