1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[2-fluoro-4-(1-pyrrolidinylcarbonyl) phenyl]-3-(trifluoromethyl)-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[2-fluoro-4-(1-pyrrolidinylcarbonyl) phenyl]-3-(trifluoromethyl)-
CAS No.:218298-94-3
Molecular Formula:C23H18F4N6O3
Molecular Weight:502.428
Hs Code.:
Mol file:218298-94-3.mol

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[2-fluoro-4-(1-pyrrolidinylcarbonyl) phenyl]-3-(trifluoromethyl)-

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Technology Process of 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[2-fluoro-4-(1-pyrrolidinylcarbonyl) phenyl]-3-(trifluoromethyl)-

There total 12 articles about 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[2-fluoro-4-(1-pyrrolidinylcarbonyl) phenyl]-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855869-58-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(pyrrolidine-1-carbonyl)-phenyl]-amide

: 218298-94-3
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenyl-aminocarbonyl]pyrazole

Guidance literature:: 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(pyrrolidine-1-carbonyl)-phenyl]-amide; With acetoxyhydroxamic acid; potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

With hydrogenchloride; In ethanol; at 80 ℃;
DOI:10.1021/jm0497949

Reference yield:

: 446-34-4
2-fluoro-4-methyl-1-nitrobenzene

: 218298-94-3
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenyl-aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 82 percent / potassium dichromate; acetic acid; sulfuric acid / 1.5 h / 120 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 5 h / 0 °C

3.1: 24.5 g / triethylamine / CH₂Cl₂ / 48 h / 20 °C

4.1: 55 percent / H₂ / Pd/C / methanol / 0.5 h / 1551.44 Torr

5.1: (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

6.1: acetoxyhydroxamic acid; potassium tert-butoxide / dimethylformamide / 12 h / 20 °C

6.2: HCl / ethanol / 80 °C

With dmap; potassium dichromate; oxalyl dichloride; acetoxyhydroxamic acid; sulfuric acid; potassium tert-butylate; hydrogen; acetic acid; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949

Reference yield:

: 157665-51-5
3-fluoro-4-nitrobenzoyl chloride

: 218298-94-3
1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenyl-aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 24.5 g / triethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: 55 percent / H₂ / Pd/C / methanol / 0.5 h / 1551.44 Torr

3.1: (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: acetoxyhydroxamic acid; potassium tert-butoxide / dimethylformamide / 12 h / 20 °C

4.2: HCl / ethanol / 80 °C

With dmap; acetoxyhydroxamic acid; potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949