1H-Pyrazole-5-carboxamide, N-[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-1-( 2-oxido-7-isoquinolinyl)-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, N-[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-1-( 2-oxido-7-isoquinolinyl)-
CAS No.:218301-12-3
Molecular Formula:C30H29N5O4S
Molecular Weight:555.657
Hs Code.:
Mol file:218301-12-3.mol

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Chemical Property of 1H-Pyrazole-5-carboxamide, N-[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-1-( 2-oxido-7-isoquinolinyl)-

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Technology Process of 1H-Pyrazole-5-carboxamide, N-[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-1-( 2-oxido-7-isoquinolinyl)-

There total 3 articles about 1H-Pyrazole-5-carboxamide, N-[2'-[[(1,1-dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-1-( 2-oxido-7-isoquinolinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23707-37-1
7-aminoisoquinoline

: 218301-12-3
5-methyl-2-(2-oxy-isoquinolin-7-yl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaNO₂; aq. HCl / 0.5 h / 0 °C

1.2: SnCl₂; aq. HCl / 1 h / 0 °C

2.1: AcOH / 14 h / Heating

3.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

3.2: CH₂Cl₂; hexane / 14 h / 40 °C

4.1: m-chloroperbenzoic acid / acetone / 20 °C

With hydrogenchloride; trimethylaluminum; acetic acid; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In hexane; dichloromethane; acetone;
DOI:10.1021/jm020578e

Reference yield:

: 218301-10-1
ethyl 1-(isoquinolyn-7'-yl)-3-methyl-5-pyrazole carboxylate

: 218301-12-3
5-methyl-2-(2-oxy-isoquinolin-7-yl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

1.2: CH₂Cl₂; hexane / 14 h / 40 °C

2.1: m-chloroperbenzoic acid / acetone / 20 °C

With trimethylaluminum; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane; acetone;
DOI:10.1021/jm020578e

Reference yield:

: isoquinolin-7-yl-hydrazine; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 218301-12-3
5-methyl-2-(2-oxy-isoquinolin-7-yl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH / 14 h / Heating

2.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

2.2: CH₂Cl₂; hexane / 14 h / 40 °C

3.1: m-chloroperbenzoic acid / acetone / 20 °C

With trimethylaluminum; acetic acid; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane; acetone;
DOI:10.1021/jm020578e