1H-Pyrazole-5-carboxylic acid, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-3-(trifluoromethyl)- , methyl ester

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-3-(trifluoromethyl)- , methyl ester
CAS No.:218301-84-9
Molecular Formula:C16H13F3N4O3
Molecular Weight:366.299
Hs Code.:
Mol file:218301-84-9.mol

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-3-(trifluoromethyl)- , methyl ester

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Technology Process of 1H-Pyrazole-5-carboxylic acid, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-3-(trifluoromethyl)- , methyl ester

There total 6 articles about 1H-Pyrazole-5-carboxylic acid, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-3-(trifluoromethyl)- , methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 218301-83-8
methyl 1-(4'-fluoro-3'-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid ester

: 127-06-0
acetone oxime

: 218301-84-9
methyl 1-(4'-isopropylideneaminooxy-3'-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid ester

Guidance literature:: acetone oxime; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

methyl 1-(4'-fluoro-3'-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/jm0497949

Reference yield:

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 218301-84-9
methyl 1-(4'-isopropylideneaminooxy-3'-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.93 g / 0.5 h / Heating

2.1: t-BuOK / dimethylformamide; tetrahydrofuran / 0.25 h / 20 °C

2.2: 68 percent / dimethylformamide; tetrahydrofuran / 20 h / 20 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 218301-84-9
methyl 1-(4'-isopropylideneaminooxy-3'-cyanophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2.1: 1.93 g / 0.5 h / Heating

3.1: t-BuOK / dimethylformamide; tetrahydrofuran / 0.25 h / 20 °C

3.2: 68 percent / dimethylformamide; tetrahydrofuran / 20 h / 20 °C

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949