8-BroMo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Base Information

• Chemical Name: 8-BroMo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
• CAS No.: 218431-08-4
• Molecular Formula: C10H10BrClN4O
• Molecular Weight: 317.57000
• Hs Code.: 2933998090
• Mol file: 218431-08-4.mol

Synonyms:8-Bromo-6-chloro-9-(tetrahydro-pyran-2-yl)-9H-purine;8-BROMO-6-CHLORO-9-(TETRAHYDRO-2H-PYRAN-2-YL)-9H-PURINE;

Chemical Property of 8-BroMo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Chemical Property:

• PSA: 52.83000
• LogP: 2.94130

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BroMo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

There total 1 articles about 8-BroMo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.6%

6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (7306-68-5) → 8-bromo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (218431-08-4)

Guidance literature:

6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With dibromotetrachloroethane; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c01717

Reference yield: 61.0%

tributylphenylstannane (960-16-7) + 8-bromo-6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (218431-08-4) → 6-chloro-8-phenyl-9H-purine

Guidance literature:

tetratrifurylphosphinepalladium; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.3891/acta.chem.scand.53-0366

upstream raw materials:

6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

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