1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid
CAS No.:218631-44-8
Molecular Formula:C12H12N2O3
Molecular Weight:232.239
Hs Code.:2933199090
European Community (EC) Number:621-743-2
DSSTox Substance ID:DTXSID80377782
Wikidata:Q82167140
Mol file:218631-44-8.mol

Synonyms:218631-44-8;1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid;2-(4-methoxyphenyl)-5-methylpyrazole-3-carboxylic acid;2-(4-METHOXY-PHENYL)-5-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID;2-(4-methoxyphenyl)-5-methyl-2h-pyrazole-3-carboxylic acid;1-(4-METHOXYPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLICACID;SCHEMBL1873948;DTXSID80377782;KGDRXQSJRQQXCK-UHFFFAOYSA-N;2-(4-METHOXY-PHENYL)-5-METHYL-2H-PYRAZOLE-3-CARBOXYLICACID;MFCD05150587;AKOS022671641;KS-9064;FT-0721347

Suppliers and Price of 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylicacid 97%
5g
$ 986.00

American Custom Chemicals Corporation
1-(4-METHOXYPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 95.00%
10G
$ 7882.88

American Custom Chemicals Corporation
1-(4-METHOXYPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 95.00%
5G
$ 4244.63

American Custom Chemicals Corporation
1-(4-METHOXYPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 95.00%
1G
$ 1030.84

American Custom Chemicals Corporation
1-(4-METHOXYPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 95.00%
100MG
$ 144.90

AK Scientific
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylicacid
1g
$ 468.00

AK Scientific
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylicacid
250mg
$ 178.00

AK Scientific
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylicacid
100mg
$ 117.00

Total 6 raw suppliers

Chemical Property of 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

Chemical Property:

Vapor Pressure:9.64E-08mmHg at 25°C
Boiling Point:418.2oC at 760 mmHg
PKA:3.41±0.36(Predicted)
Flash Point:206.7oC
PSA：64.35000
Density:1.26g/cm3
LogP:1.88750
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:232.08479225
Heavy Atom Count:17
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=NN(C(=C1)C(=O)O)C2=CC=C(C=C2)OC

Technology Process of 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

There total 2 articles about 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218632-36-1
ethyl 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate

: 218631-44-8
1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: ethyl 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate; With sodium hydroxide; ethanol; water; at 45 ℃;

With hydrogenchloride; water; In ethanol; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 615-79-2
ethyl 2,4-diketopentanoate

: 218631-44-8
1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 1 h / 0 °C

1.2: 4 h / 20 °C

2.1: water; sodium hydroxide / 2 h / Reflux

With water; sodium hydroxide; In ethanol;
DOI:10.3184/174751911X13149561530439

Reference yield: 71.1%

: 218631-44-8
1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

: 84568-64-9
2-(5-fluorouracil-1-yl)-N-(2-hydroxyethyl)acetamide

: 1448994-18-0
2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate

Guidance literature:: 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid; With dmap; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 0.5h;

2-(5-fluorouracil-1-yl)-N-(2-hydroxyethyl)acetamide; In N,N-dimethyl-formamide;
DOI:10.3184/174751914X13955977912102