Technology Process of Cinnolin-8-amine
There total 10 articles about Cinnolin-8-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(III) chloride;
In
acetic acid;
at 11 ℃;
for 0.116667h;
- Guidance literature:
-
cinnoline-8-carboxylic acid;
With
diphenylphosphoranyl azide; triethylamine;
In
1,4-dioxane;
at 20 ℃;
for 1.33333h;
With
water;
In
1,4-dioxane;
at 100 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / 16 h / 100 °C
2.1: sodium iodide; copper(l) iodide / 1,4-dioxane / 0.25 h / Sealed tube; Inert atmosphere
2.2: 16 h / 110 °C / Inert atmosphere
3.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 3 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride; sodium nitrite / water; tetrahydrofuran; acetonitrile / 0.25 h / -5 °C
4.2: 1.5 h / 0 - 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C
6.1: 1,2-dichloro-benzene / 0.5 h / 200 °C / Sealed tube
7.1: lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C
8.1: triethylamine; diphenylphosphoranyl azide / 1,4-dioxane / 1.33 h / 20 °C
8.2: 48 h / 100 °C
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; triethylamine; sodium iodide; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-benzene; acetonitrile;
