20776-51-6

Basic information

• Product Name: 2-AMINO-3-BROMOBENZOIC ACID
• Synonyms: 2-AMino-3-broMobenzoic acid, 95+%;3-Bromoanthralic acid, 2-Bromo-6-carboxyaniline;Benzoic acid, 2-amino-3-bromo-;2-AMINO-3-BROMOBENZOIC ACID;AURORA KA-6184;BUTTPARK 49\07-48;2-Amino-3-bromobenzoic acid 97%;3-Bromoanthralic acid
• CAS NO: 20776-51-6
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.03
• EINECS: 1533716-785-6
• Product Categories: Chemical Synthesis;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Carboxylic Acids;Phenyls & Phenyl-Het;Amines;Building Blocks;C7
• Mol File: 20776-51-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 343.5 °C at 760 mmHg
• Flash Point: 161°C
• Appearance: White to pale yellow/Solid
• Density: 1.793 g/cm³
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-BROMOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BROMOBENZOIC ACID(20776-51-6)
• EPA Substance Registry System: 2-AMINO-3-BROMOBENZOIC ACID(20776-51-6)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 22-36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 20776-51-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Used as pharmaceutical intermediates.

InChI:InChI=1/C7H6BrNO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,9H2,(H,10,11)/p-1

Upstream product

• 116529-61-4 3-bromo-2-nitrobenzoic acid 
• 7647-01-0 hydrogenchloride 
• 118-92-3 anthranilic acid 
• 91-56-5 indole-2,3-dione 
• 101080-38-0 N-(2-bromo-phenyl)-2-[(E)-hydroxyimino]acetamine 
• 89-52-1 o-acetylamino-benzoic acid 
• 861791-77-7 2-acetylamino-3-bromo-benzoic acid 
• 20780-74-9 7-bromoisatin 
• 101080-38-0 N-(2-bromophenyl)-2-isonitrosoacetanilide 
• 615-36-1 2-bromoaniline 
• 104670-74-8 methyl 2-amino-3-bromobenzoate 

Downstream Products

• 104670-74-8 methyl 2-amino-3-bromobenzoate 
• 221298-75-5 2-methyl-4-chloro-8-bromo-quinazoline 
• 1268520-96-2 C₁₀H₉N₃O₂ 
• 1341038-12-7 8-bromo-3-methyl-3H-quinazolin-4-one 
• 1410975-92-6 (7aS,9S)-6-(3-methyl-4-oxo-3,4-dihydroquinazolin-8-yl)-2-methylthio-9-(4-nitrobenzoyloxy)-6,7,7a,8,9,10-hexahydro-5H-pyrimido[5,4-f]pyrrolo[1,2-a][1,4]diazepin-5-one 
• 1022960-45-7 2-amino-3-bromo-N-methylbenzamide 
• 1368204-76-5 2-amino-3-bromo-N-ethylbenzamide 
• 1367962-46-6 2-amino-3-bromo-N-(2-methoxyethyl)benzamide 
• 1410974-23-0 2-amino-3-bromo-N-(2-hydroxyethyl)benzamide 
• 121772-84-7 methyl 2-iodo-3-bromobenzoic acid 

Relevant articles and documents

Bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof

The invention discloses a bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof. The invention provides the bicyclic heteroaryl compound with PAR4 antagonistic activity,and the bicyclic heteroaryl compound has remarkable antagonistic activity on PAR4 in an in-vitro anti-platelet aggregation experiment, so that platelet aggregation is effectively inhibited, and the bicyclic heteroaryl compound can be used for preparing medicines for preventing or treating various thromboembolic diseases.

Br?nsted Acid-Catalyzed Asymmetric Ring-Closing Alkylation of Inert N-substituted Pyrroles with α, β-Unsaturated Ketones

A Chiral Br?nsted acid catalyzed asymmetric intramolecular ring-closing alkylation of inert pyrroles with α, β-unsaturated ketones has been developed. This approach gave a wide range of 4-phenyl-4,5-dihydro-6H-benzo[f]pyrrolo[1,2-a]azepin-6-ones in high yields with good enantioselectivities under mild reaction conditions. (Figure presented.).

PYRIMIDO-DIAZEPINONE COMPOUND

Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, (wherein Ra represents a hydrogen atom or the like, R1 and R2 may be the same or different, and each represents a hydrogen atom, optionally substituted lower alkyl or cycloalkyl, or R1 and R2 are combined together with the adjacent nitrogen atom thereto to form nitrogen-containing heterocyclic group, and Z represents a bicyclic heterocyclic group in which optionally substituted two six-membered rings are fused to each other, or the like) and the like.