8-Hydroxy-4',5,7-trimethoxyflavone

Base Information

Chemical Name:8-Hydroxy-4',5,7-trimethoxyflavone
CAS No.:21919-71-1
Molecular Formula:C18H16O6
Molecular Weight:328.321
Hs Code.:
UNII:JEU93A5YP5
DSSTox Substance ID:DTXSID601167770
Nikkaji Number:J546.512E
Wikidata:Q104911703
Metabolomics Workbench ID:49141
Mol file:21919-71-1.mol

Synonyms:8-Hydroxy-4',5,7-trimethoxyflavone;JEU93A5YP5;UNII-JEU93A5YP5;8-Hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;21919-71-1;8-hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one;CHEBI:174405;DTXSID601167770;4',5,7-Trimethoxy-8-hydroxyflavone;8-hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

Suppliers and Price of 8-Hydroxy-4',5,7-trimethoxyflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Hydroxy-4',5,7-trimethoxyflavone

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:328.09468823
Heavy Atom Count:24
Complexity:482

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)O

Technology Process of 8-Hydroxy-4',5,7-trimethoxyflavone

There total 6 articles about 8-Hydroxy-4',5,7-trimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 89456-28-0
8-Benzyloxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

: 21919-71-1
8-Hydroxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1246/bcsj.56.3773

Reference yield:

: 54299-57-9
3-benzyloxy-2-hydroxy-4,6-dimethoxyacetophenone

: 21919-71-1
8-Hydroxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 2 h / 120 °C

2: KOH, pyridine / 4 h / 60 °C

3: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C

4: 84 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

With pyridine; potassium hydroxide; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate;
DOI:10.1246/bcsj.56.3773

Reference yield:

: 89456-13-3
2,3-bis(benzyloxy)-4,6-dimethoxyacetophenone

: 21919-71-1
8-Hydroxy-5,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature

2: pyridine / 2 h / 120 °C

3: KOH, pyridine / 4 h / 60 °C

4: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C

5: 84 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

With pyridine; hydrogenchloride; potassium hydroxide; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate;
DOI:10.1246/bcsj.56.3773