((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane
CAS No.:220018-20-2
Molecular Formula:C₁₉H₃₄O₃Si
Molecular Weight:338.563
Hs Code.:

Synonyms:((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of ((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

There total 4 articles about ((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 220018-17-7
(2R,3R)-2-Benzyloxymethoxy-pentan-3-ol

: 220018-20-2
((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 36h;
DOI:10.1039/a805856c

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 220018-20-2
((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / diisopropylethylamine / 18 h / Ambient temperature

2: 75 percent / diisobutylaluminium hydride / hexane / 1.5 h / -78 °C

3: 1.) ZnBr₂ / 1.) Et₂O, 0 deg C, 0.5 h, 2.) Et₂O, 0 deg C, 25 min, 4 h

4: 94 percent / imidazole / dimethylformamide / 36 h

With 1H-imidazole; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; zinc dibromide; In hexane; N,N-dimethyl-formamide;
DOI:10.1039/a805856c

Reference yield:

: 159572-27-7
(R)-2-((benzyloxy)methoxy)propanal

: 220018-20-2
((1R,2R)-2-Benzyloxymethoxy-1-ethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ZnBr₂ / 1.) Et₂O, 0 deg C, 0.5 h, 2.) Et₂O, 0 deg C, 25 min, 4 h

2: 94 percent / imidazole / dimethylformamide / 36 h

With 1H-imidazole; zinc dibromide; In N,N-dimethyl-formamide;
DOI:10.1039/a805856c