1-N-BOC-MORPHOLINE

Base Information

• Chemical Name: 1-N-BOC-MORPHOLINE
• CAS No.: 220199-85-9
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.239
• Hs Code.: 2934999090
• Mol file: 220199-85-9.mol

Synonyms:tert-butyl 4-morpholinecarboxylate;1-N-Boc-Morpholine;morpholine-4-carboxylic acid tert-butyl ester;N-Boc-morpholine;4-Morpholinecarboxylic acid,1,1-dimethylethyl ester;

Chemical Property of 1-N-BOC-MORPHOLINE

Chemical Property:

• Vapor Pressure: 0.018mmHg at 25°C
• Melting Point: 57-60℃
• Boiling Point: 253.836oC at 760 mmHg
• Flash Point: 107.317oC
• PSA: 38.77000
• Density: 1.065g/cm3
• LogP: 1.19160
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-ButylMorpholine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-MORPHOLINE

There total 11 articles about 1-N-BOC-MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + di-tert-butyl dicarbonate (24424-99-5) → morpholine-4-carboxylic acid tert-butyl ester (220199-85-9)

Guidance literature:

With lanthanum(III) nitrate; at 20 ℃; for 0.0333333h;

DOI:10.1016/j.tetlet.2006.09.081

Reference yield: 98.0%

morpholine-4-carboxylic acid (50881-96-4) + di-tert-butyl dicarbonate (24424-99-5) → morpholine-4-carboxylic acid tert-butyl ester (220199-85-9)

Guidance literature:

With 1-butyl-3-methylimidazolium trifluoroacetate; In neat (no solvent); at 20 ℃; for 0.25h; chemoselective reaction;

DOI:10.1039/c4ra02670e

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + 2,2-dimethylpropanoic anhydride (1538-75-6) → morpholine-4-carboxylic acid tert-butyl ester (220199-85-9)

Guidance literature:

With zinc(II) chloride; In dichloromethane; at 20 ℃; for 0.25h;

upstream raw materials:

di-tert-butyl dicarbonate

allyl morpholine-4-carboxylate

morpholine

tert-butyl 1H-imidazole-1-carboxylate

Downstream raw materials:

2H-1,4-oxazin-4(3H)-carboxylic acid tert-butyl ester

tert-butyl 3-cyanomorpholine-4-carboxylate

tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate

Refernces

• 1、 Garad, Dnyaneshwar N.,Ingale, Ajit P.,Shinde, Sandeep V.,Ukale, Dattatraya. "Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions". supporting information. p. 1656 - 1668. Retrieved 2021/04/05.
• 2、 Ingale, Ajit P.,Garad, Dnyaneshwar N.,Ukale, Dattatraya,Thorat, Nitin M.,Shinde, Sandeep V.. "Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines". supporting information. p. 3791 - 3804. Retrieved 2021/11/04.