tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate

Base Information

• Chemical Name: tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate
• CAS No.: 1221347-27-8
• Molecular Formula: C9H15NO3
• Molecular Weight: 185.22
• Hs Code.: 2934999090
• Mol file: 1221347-27-8.mol

Synonyms:tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate;1-Boc-2,3-dihydro-[1,4]oxazine;3,4-Dihydro-2H-1,4-oxazine,N-BOCprotected

Chemical Property of tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate

Chemical Property:

• Boiling Point: 244.9±33.0 °C(Predicted)
• PKA: -1.01±0.20(Predicted)
• PSA: 38.77000
• Density: 1.095±0.06 g/cm3(Predicted)
• LogP: 1.66280

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-2,3-Dihydro-[1,4]oxazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate

There total 3 articles about tert-butyl 2H-1,4-oxazine-4(3H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ 2H-1,4-oxazin-4(3H)-carboxylic acid tert-butyl ester (1221347-27-8)

Guidance literature:

With 2,4,6-trimethyl-pyridine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; CyJohnPhos; In N,N-dimethyl acetamide; at 20 ℃; for 15h; Schlenk technique; Inert atmosphere; Irradiation;

Reference yield: 52.0%

morpholine-4-carboxylic acid tert-butyl ester (220199-85-9) → 2H-1,4-oxazin-4(3H)-carboxylic acid tert-butyl ester (1221347-27-8)

Guidance literature:

With manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride; [bis(acetoxy)iodo]benzene; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1021/acscatal.9b03457

Reference yield:

tert-butyl 3-methoxymorpholine-4-carboxylate (195964-53-5) → 2H-1,4-oxazin-4(3H)-carboxylic acid tert-butyl ester (1221347-27-8)

Guidance literature:

In methanol; at 70 ℃; for 3h; under 100 Torr;

DOI:10.1002/adsc.202000450

upstream raw materials:

morpholine-4-carboxylic acid tert-butyl ester

tert-butyl 3-methoxymorpholine-4-carboxylate