8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-2,3-diphenyl-, (1R,5S)-

Base Information

Chemical Name:8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-2,3-diphenyl-, (1R,5S)-
CAS No.:220455-63-0
Molecular Formula:C20H21N
Molecular Weight:275.393
Hs Code.:
Mol file:220455-63-0.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-2,3-diphenyl-, (1R,5S)-

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Technology Process of 8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-2,3-diphenyl-, (1R,5S)-

There total 12 articles about 8-Azabicyclo[3.2.1]oct-2-ene, 8-methyl-2,3-diphenyl-, (1R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 220455-64-1
(R)-3-phenyl-2-tropinone 2-triflate

: 98-80-6
phenylboronic acid

: 220455-63-0
2,3-diphenyl-2-tropene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In various solvent(s); for 1h; Heating;
DOI:10.1021/jm0582423

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 220455-63-0
2,3-diphenyl-2-tropene

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

1.2: 92 percent / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

3.1: aq. potassium hydroxide / 0.5 h / Heating

4.1: diphenylphosphorylazide; triethylamine / toluene / Heating

5.1: toluene / 8 h / Heating

6.1: 1.06 g / aq. HCl / 1 h / Heating

7.1: 34 percent / diethyl ether / 11 h / 20 °C

8.1: aq. HBr / 0.25 h / Heating

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; hydrogen bromide; sodium hexamethyldisilazane; triethylamine; cesium fluoride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jm0582423

Reference yield:

: 168143-65-5
methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate

: 220455-63-0
2,3-diphenyl-2-tropene

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

2: aq. potassium hydroxide / 0.5 h / Heating

3: diphenylphosphorylazide; triethylamine / toluene / Heating

4: toluene / 8 h / Heating

5: 1.06 g / aq. HCl / 1 h / Heating

6: 34 percent / diethyl ether / 11 h / 20 °C

7: aq. HBr / 0.25 h / Heating

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; hydrogen bromide; triethylamine; cesium fluoride; In diethyl ether; toluene;
DOI:10.1021/jm0582423