(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

Base Information

Chemical Name:(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene
CAS No.:220455-65-2
Molecular Formula:C₂₆H₂₃NO₂
Molecular Weight:381.474
Hs Code.:

Synonyms:(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

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Chemical Property of (R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

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Technology Process of (R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

There total 11 articles about (R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1885-14-9
phenyl chloroformate

: 220455-63-0
2,3-diphenyl-2-tropene

: 220455-65-2
(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm0582423

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 220455-65-2
(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

1.2: 92 percent / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

3.1: aq. potassium hydroxide / 0.5 h / Heating

4.1: diphenylphosphorylazide; triethylamine / toluene / Heating

5.1: toluene / 8 h / Heating

6.1: 1.06 g / aq. HCl / 1 h / Heating

7.1: 34 percent / diethyl ether / 11 h / 20 °C

8.1: aq. HBr / 0.25 h / Heating

9.1: 94 percent / NaHCO₃ / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; hydrogen bromide; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; cesium fluoride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm0582423

Reference yield:

: 168143-65-5
methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate

: 220455-65-2
(R)-N-phenoxycarbonyl-2,3-diphenyl-2-tropene

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / tetrakis(triphenylphosphine)palladium; cesium fluoride / various solvent(s) / 2 h / 60 °C

2: aq. potassium hydroxide / 0.5 h / Heating

3: diphenylphosphorylazide; triethylamine / toluene / Heating

4: toluene / 8 h / Heating

5: 1.06 g / aq. HCl / 1 h / Heating

6: 34 percent / diethyl ether / 11 h / 20 °C

7: aq. HBr / 0.25 h / Heating

8: 94 percent / NaHCO₃ / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; hydrogen bromide; sodium hydrogencarbonate; triethylamine; cesium fluoride; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm0582423