L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

Base Information

Chemical Name:L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)
CAS No.:220545-24-4
Molecular Formula:C₂₆H₃₇N₅O₇S₂
Molecular Weight:595.741
Hs Code.:
Mol file:220545-24-4.mol

L-Tyrosine,
N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin
yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

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Chemical Property of L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

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Technology Process of L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester)

There total 5 articles about L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1,1-dimethylethyl ester, dimethylcarbamate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: L-tyrosine tert-butyl ester hydrochloride

: 220545-24-4
N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

2: K₂CO₃

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
DOI:10.1016/j.bmcl.2004.01.062

Reference yield:

: 72778-00-8
(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 220545-24-4
N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃

2: N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

3: K₂CO₃

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
DOI:10.1016/j.bmcl.2004.01.062

Reference yield:

: 693226-09-4
5,5-dimethyl-3-(1-methyl-1H-pyrazole-4-sulfonyl)-thiazolidine-4-carboxylic acid

: 220545-24-4
N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

2: K₂CO₃

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
DOI:10.1016/j.bmcl.2004.01.062