L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1-methylethyl ester, dimethylcarbamate (ester)

Base Information

• Chemical Name: L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1-methylethyl ester, dimethylcarbamate (ester)
• CAS No.: 220545-48-2
• Molecular Formula: C25H35N5O7S2
• Molecular Weight: 581.714
• Mol file: 220545-48-2.mol

Synonyms:

Chemical Property of L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1-methylethyl ester, dimethylcarbamate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1-methylethyl ester, dimethylcarbamate (ester)

There total 4 articles about L-Tyrosine, N-[[(4R)-5,5-dimethyl-3-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4-thiazolidin yl]carbonyl]-, 1-methylethyl ester, dimethylcarbamate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (72778-00-8) → N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine isopropyl ester (220545-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. K₂CO₃

2: N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

3: K₂CO₃

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/j.bmcl.2004.01.062

Reference yield:

5,5-dimethyl-3-(1-methyl-1H-pyrazole-4-sulfonyl)-thiazolidine-4-carboxylic acid (693226-09-4) → N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine isopropyl ester (220545-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

2: K₂CO₃

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/j.bmcl.2004.01.062

Reference yield:

N,N-Dimethylcarbamoyl chloride (79-44-7) + (S)-2-{[(R)-5,5-Dimethyl-3-(1-methyl-1H-pyrazole-4-sulfonyl)-thiazolidine-4-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionic acid isopropyl ester → N-(1-methylpyrazole-4-sulfonyl)-L-(5,5-dimethyl)thiaprolyl-L-4-(N,N-dimethylcarbamyloxy)phenylalanine isopropyl ester (220545-48-2)

Guidance literature:

With potassium carbonate;

DOI:10.1016/j.bmcl.2004.01.062

upstream raw materials:

N,N-Dimethylcarbamoyl chloride

(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

5,5-dimethyl-3-(1-methyl-1H-pyrazole-4-sulfonyl)-thiazolidine-4-carboxylic acid