Spiro[2.5]octan-4-one

Base Information

• Chemical Name: Spiro[2.5]octan-4-one
• CAS No.: 2205-98-3
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.183
• Mol file: 2205-98-3.mol

Synonyms:spiro(5.2)octan-4-one;Spiro[2,5]octan-4-one;spiro[2.5]octan-4-one;Spiro (2.5)-octanon-(4);Spiro-(2,5)-octanon-(4);spiro[2.5]octane-4-one;

Chemical Property of Spiro[2.5]octan-4-one

Chemical Property:

• PSA: 17.07000
• LogP: 1.90970

Purity/Quality:

95% ^*data from raw suppliers

Spiro[2.5]octan-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[2.5]octan-4-one

There total 16 articles about Spiro[2.5]octan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Oxo-phenyl-acetic acid spiro[2.5]oct-4-yl ester (143618-68-2) → spiro[2.5]octan-4-one (2205-98-3)

Guidance literature:

Irradiation;

DOI:10.1021/ja00048a057

Reference yield: 90.0%

spiro[2.5]octane (185-65-9) → spiro[2.5]octan-6-one (15811-21-9) + spiro[2.5]octan-5-one (25308-67-2) + spiro[2.5]octan-4-one (2205-98-3)

Guidance literature:

With methyltrifluoromethyldioxirane; In dichloromethane; at 0 ℃; for 0.583333h;

DOI:10.1021/jo034768o

Reference yield: 90.0%

spiro[2.5]octane (185-65-9) → spiro[2.5]octan-4-one (2205-98-3)

Guidance literature:

With Oxone; 1,1,1-trifluoro-2-propanone; sodium hydrogencarbonate; In water; at -70 - 0 ℃; for 0.583333h;

DOI:10.1002/ejoc.201701671

upstream raw materials:

spiro<2.5>octan-4-ol

dimethylsulfoxonium methylide

2-Chlorocyclohexanone

Spiro<2.5>dec-4-en-4-yl-trifluormethansulfonat

Downstream raw materials:

2-ethylcyclohexanone

2-<2-(1'-Cyclohexenylethyl)>-spiro<2.5>octan

cis-5-(4-methoxybenzyl)-spiro<5,2>-octan-4-ol

(4R,5R)-5-(4-Methoxy-benzyl)-spiro[2.5]octan-4-ol

Refernces

• 1、 Crandall,J.K.,Seidewand,R.J.. "-". . p. 697 - 701. Retrieved 1970.
• 2、 Ruder, Suzanne M.,Ronald, Robert C.. "2-CHLOROETHYL DIMETHYL SULFONIUM IODIDE.". . p. 5501 - 5504. Retrieved 1984.
• 3、 Tsuji,T. et al.. "-". . p. 2344 - 2349. Retrieved 1967.
• 4、 Sedenkova, Kseniya N.,Andriasov, Kristian S.,Stepanova, Svetlana A.,Gloriozov, Igor P.,Grishin, Yuri K.,Kuznetsova, Tamara S.,Averina, Elena B.. "Direct Oxidation of Cyclopropanated Cyclooctanes as a Synthetic Approach to Polycyclic Cyclopropyl Ketones". . p. 879 - 884. Retrieved 2018/02/27.
• 5、 -. "N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives". Page/Page column 10. . Retrieved 2010/11/25.