(S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole
CAS No.:220628-97-7
Molecular Formula:C₁₉H₁₆N₂O
Molecular Weight:288.349
Hs Code.:
DSSTox Substance ID:DTXSID50458850
Nikkaji Number:J1.032.665F
Wikidata:Q82282399
Mol file:220628-97-7.mol

Synonyms:220628-97-7;(S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole;Quinoline, 8-[(4S)-4,5-dihydro-4-(phenylmethyl)-2-oxazolyl]-;CTK0J6784;DTXSID50458850;8-(4beta-Benzyl-2-oxazoline-2-yl)quinoline;F72140

Suppliers and Price of (S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole

Chemical Property:

Boiling Point:479.5±18.0 °C(Predicted)
PSA：34.48000
Density:1.19±0.1 g/cm3(Predicted)
LogP:3.05850
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:288.126263138
Heavy Atom Count:22
Complexity:402

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(N=C(O1)C2=CC=CC3=C2N=CC=C3)CC4=CC=CC=C4
Isomeric SMILES:C1[C@@H](N=C(O1)C2=CC=CC3=C2N=CC=C3)CC4=CC=CC=C4

Technology Process of (S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole

There total 5 articles about (S)-4-Benzyl-2-(quinolin-8-yl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86-59-9
8-carboxyquinoline

: 220628-97-7
(4'R)-8-(3',4'-dihydro-4'-benzyl-2'-oxazolyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 8 h / Heating

2: Et₃N / CHCl₃ / 24 h / Heating

3: 76 percent / SOCl₂ / CHCl₃ / 1 h / Heating

4: 69 percent / NaOH / methanol / 15 h / Heating

With sodium hydroxide; thionyl chloride; triethylamine; In methanol; chloroform;
DOI:10.1016/S0957-4166(98)00455-8

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 220628-97-7
(4'R)-8-(3',4'-dihydro-4'-benzyl-2'-oxazolyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄, I₂ / tetrahydrofuran

2: Et₃N / CHCl₃ / 24 h / Heating

3: 76 percent / SOCl₂ / CHCl₃ / 1 h / Heating

4: 69 percent / NaOH / methanol / 15 h / Heating

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; iodine; triethylamine; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0957-4166(98)00455-8

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 220628-97-7
(4'R)-8-(3',4'-dihydro-4'-benzyl-2'-oxazolyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 24 h / Heating

2: 76 percent / SOCl₂ / CHCl₃ / 1 h / Heating

3: 69 percent / NaOH / methanol / 15 h / Heating

With sodium hydroxide; thionyl chloride; triethylamine; In methanol; chloroform;
DOI:10.1016/S0957-4166(98)00455-8