L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-

Base Information

Chemical Name:L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-
CAS No.:220846-33-3
Molecular Formula:C24H19Cl3N2O4
Molecular Weight:505.785
Hs Code.:
Mol file:220846-33-3.mol

Synonyms:(S)-2-(2-Chloro-6-methyl-benzoylamino)-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid;4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[(2-chloro-6-methylphenyl)carbonyl]-L-phenylalanine;N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine;

Suppliers and Price of L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-

Chemical Property:

Boiling Point:633.0±55.0 °C(Predicted)
PSA：95.50000
Density:1.447±0.06 g/cm3(Predicted)
LogP:6.09710

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-

There total 2 articles about L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 220846-22-0
4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[(2-chloro-6-methylphenyl)-carbonyl]-L-phenylalanine methyl ester

: 220846-33-3
Ro 0270608

Guidance literature:: 4-[[(2,6-dichlorophenyl)carbonyl]amino]-N-[(2-chloro-6-methylphenyl)-carbonyl]-L-phenylalanine methyl ester; With sodium hydroxide; water;

With hydrogenchloride; In Isopropyl acetate;

Reference yield:

: 219529-84-7
4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester

: 220847-11-0
4-amino-N-[(2-chloro-6-methylphenyl)carbonyl]-L-phenylalanine methyl ester

: 220846-33-3
Ro 0270608

Guidance literature:: 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester; (2-Me-6-Cl)C₆H₃COX (X=Cl or OH); In ethanol; at 20 ℃;

With sodium hydroxide; In ethanol; at 45 - 50 ℃;
DOI:10.1016/S0960-894X(02)00387-6

Reference yield: 90.0%

: 652-67-5
Isosorbide

: 220846-33-3
Ro 0270608

: [(3S,3aR,6S,6aR)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2S)-2-[(2-chloro-6-methylbenzoyl)amino]-3-[4-[(2,6 dichlorobenzoyl)amino]phenyl]propanoate

Guidance literature:: Ro 0270608; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 0.283333h; Inert atmosphere;

Isosorbide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;