Chemical Property of Isosorbide
Chemical Property:
- Appearance/Colour:off-white to light yellow or beige crystal
- Vapor Pressure:4.71E-07mmHg at 25°C
- Melting Point:60-63 °C(lit.)
- Refractive Index:45 ° (C=5, H2O)
- Boiling Point:372.1 °C at 760 mmHg
- PKA:13.17±0.40(Predicted)
- Flash Point:178.8 °C
- PSA：58.92000
- Density:1.475 g/cm3
- LogP:-1.49420
- Storage Temp.:Refrigerator
- Sensitive.:Hygroscopic
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Water Solubility.:Soluble in alcohols, water and ketones.
- XLogP3:-1.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:146.05790880
- Heavy Atom Count:10
- Complexity:122
- Purity/Quality:
-
99.0%Min *data from raw suppliers
AT 101 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
22
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C(C2C(O1)C(CO2)O)O
- Isomeric SMILES:C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
- Recent ClinicalTrials:Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer
- Recent EU Clinical Trials:Phase I/II Study of Combined Treatment with
- Recent NIPH Clinical Trials:The clinical evaluation of the Kampo therapy for Meniere disease.
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Uses
Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators. pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics. D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.
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Biological Functions
emergency treatment of acute angle-closure glaucoma.
It should not be confused with isosorbide dinitrate, an
antianginal drug.
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Clinical Use
Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its
ophthalmologic properties are its primary value.
