2-isopropyl-6-methylbenzoic acid

Base Information

• Chemical Name: 2-isopropyl-6-methylbenzoic acid
• CAS No.: 220847-57-4
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 220847-57-4.mol

Synonyms:2-isopropyl-6-methylbenzoic acid;Benzoic acid, 2-methyl-6-(1-methylethyl)-;2-iso-propyl-6-methylbenzoic acid;

Chemical Property of 2-isopropyl-6-methylbenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.81660

Purity/Quality:

2-isopropyl-6-methylbenzoicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-isopropyl-6-methylbenzoic acid

There total 2 articles about 2-isopropyl-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-isopropyl-6-methyliodobenzene (220848-61-3) + dppp → 2-(1-methylethyl)-6-methylbenzoic acid (220847-57-4)

Guidance literature:

With sodium hydroxide; carbon monoxide; triethylamine; palladium diacetate; In water; acetonitrile;

Reference yield:

2-isopropyl-6-methyl-N-(quinolin-8-yl)benzamide → 2-(1-methylethyl)-6-methylbenzoic acid (220847-57-4)

Guidance literature:

With sulfuric acid; In water; at 120 ℃; for 24h;

DOI:10.1021/acs.joc.6b01393

Reference yield: 35.0%

2-(1-methylethyl)-6-methylbenzoic acid (220847-57-4) + 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester (219529-84-7) → 4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-(1-methyl)ethyl-6-methylphenyl)carbonyl]-L-phenylalanine methyl ester (220848-32-8)

Guidance literature:

upstream raw materials:

2-isopropyl-6-methyliodobenzene

Downstream raw materials:

2-(1-methylethyl)-6-methylbenzoyl chloride

4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-(1-methyl)ethyl-6-methylphenyl)carbonyl]-L-phenylalanine methyl ester