2-Quinoxalinecarboxylic acid, 3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester

Base Information

Chemical Name:2-Quinoxalinecarboxylic acid, 3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester
CAS No.:221165-70-4
Molecular Formula:C24H20F3N5O5
Molecular Weight:515.449
Hs Code.:

2-Quinoxalinecarboxylic acid,
3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid
azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester

Synonyms:

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Chemical Property of 2-Quinoxalinecarboxylic acid, 3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester

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Technology Process of 2-Quinoxalinecarboxylic acid, 3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester

There total 9 articles about 2-Quinoxalinecarboxylic acid, 3,4-dihydro-7-[4-[[[[(4-methylphenyl)amino]carbonyl]oxy]methyl]-1H-imid azol-1-yl]-3-oxo-6-(trifluoromethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 622-58-2,374675-64-6
p-Tolylisocyanate

: 221164-26-7
ethyl 3,4-dihydro-7-[4-(hydroxymethyl)imidazol-1-yl]-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate

: 221165-70-4
ethyl 3,4-dihydro-7-{4-[(4-methylphenylaminocarbonyloxy)methyl]imidazol-1-yl}-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1016/j.bmc.2005.08.060

Reference yield:

: 400-74-8
2-Fluoro-5-nitrobenzotrifluoride

: 221165-70-4
ethyl 3,4-dihydro-7-{4-[(4-methylphenylaminocarbonyloxy)methyl]imidazol-1-yl}-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogen; AcOH / Pd/C

2: 116 g / Et₃N / CHCl₃ / 48 h

3: 87 percent / fuming HNO₃ / 0.5 h / 0 °C

4: 78 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

5: 91 percent / acetonitrile / 16 h / 140 °C

6: 89 percent / HCl / Heating

7: 100 percent / hydrogen / Pd/Ac / ethanol / 3 h / 20 °C

8: 43 percent / ethanol / 4 h / Heating

9: 46 percent / dimethylformamide / 2 h / 60 °C

With hydrogenchloride; hydrogen; nitric acid; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; Pd/Ac; In ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2005.08.060

Reference yield:

: 2145-38-2
4-fluoro-3-(trifluoromethyl)acetanilide

: 221165-70-4
ethyl 3,4-dihydro-7-{4-[(4-methylphenylaminocarbonyloxy)methyl]imidazol-1-yl}-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / fuming HNO₃ / 0.5 h / 0 °C

2: 78 percent / K₂CO₃ / dimethylformamide / 4 h / 80 °C

3: 91 percent / acetonitrile / 16 h / 140 °C

4: 89 percent / HCl / Heating

5: 100 percent / hydrogen / Pd/Ac / ethanol / 3 h / 20 °C

6: 43 percent / ethanol / 4 h / Heating

7: 46 percent / dimethylformamide / 2 h / 60 °C

With hydrogenchloride; hydrogen; nitric acid; potassium carbonate; Pd/Ac; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2005.08.060