1H-Indole-3-acetaldehyde, 5-methoxy-

Base Information

• Chemical Name: 1H-Indole-3-acetaldehyde, 5-methoxy-
• CAS No.: 22139-72-6
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Mol file: 22139-72-6.mol

Synonyms:5-methoxyindoleacetaldehyde;1H-Indole-3-acetaldehyde,5-methoxy;3-Formylmethyl-5-methoxy-indol;5-methoxyindole-3-acetaldehyde;

Chemical Property of 1H-Indole-3-acetaldehyde, 5-methoxy-

Chemical Property:

• PSA: 42.09000
• LogP: 1.91790

Purity/Quality:

99% ^*data from raw suppliers

5-methoxy-1H-Indole-3-acetaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Methoxyindoleacetaldehyde is an analogue of Clozapine(C587500) which is an antipsychotic.

Technology Process of 1H-Indole-3-acetaldehyde, 5-methoxy-

There total 7 articles about 1H-Indole-3-acetaldehyde, 5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

5-methoxytryptophan (28052-84-8) → 2-(5-methoxy-1H-indol-3-yl)ethanal (22139-72-6)

Guidance literature:

With sodium hypochlorite; In water; toluene; pH=9;

DOI:10.1071/CH03030

Reference yield:

5-methoxytryptophol (712-09-4) → 2-(5-methoxy-1H-indol-3-yl)ethanal (22139-72-6)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 2h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201801012

Reference yield:

C12H13NO2 → 2-(5-methoxy-1H-indol-3-yl)ethanal (22139-72-6)

Guidance literature:

With hydrogenchloride; In water; for 3h; Reflux;

DOI:10.1039/c4ob02107j

upstream raw materials:

5-methoxytryptophan

5-methoxyindole-3-carboxaldehyde

5-methoxylindole

5-methoxy-1H-indole-3-acetic acid