1-N-BOC-4-(4-AMINOBENZYL) PIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(4-AMINOBENZYL) PIPERIDINE
• CAS No.: 221532-96-3
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Hs Code.: 2933399090
• Mol file: 221532-96-3.mol

Synonyms:

Chemical Property of 1-N-BOC-4-(4-AMINOBENZYL) PIPERIDINE

Chemical Property:

• PSA: 55.56000
• LogP: 3.97750
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

4-(4-Amino-benzyl)-piperidine-1-carboxylicacidtert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-BOC-4-(4-AMINOBENZYL) PIPERIDINE

There total 11 articles about 1-N-BOC-4-(4-AMINOBENZYL) PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 4-(4-nitrobenzyl)piperidine-1-carboxylate (333987-05-6) → 4-(4-aminobenzyl)piperidine-1-carboxylic acid tert-butyl ester (221532-96-3)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In tetrahydrofuran; for 18h; Heating;

DOI:10.1016/j.bmc.2004.10.013

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(piperidin-4-ylmethyl)-phenylamine (37581-35-4) → 4-(4-aminobenzyl)piperidine-1-carboxylic acid tert-butyl ester (221532-96-3)

Guidance literature:

In tetrahydrofuran;

Reference yield:

2,2,2-trifluoro-N-( 4-(piperidin-4-ylmethyl)phenyl)acetamide (221532-98-5) + di-tert-butyl dicarbonate (24424-99-5) → 4-(4-aminobenzyl)piperidine-1-carboxylic acid tert-butyl ester (221532-96-3)

Guidance literature:

2,2,2-trifluoro-N-( 4-(piperidin-4-ylmethyl)phenyl)acetamide; di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 0 ℃;

With sodium hydroxide; at 0 - 20 ℃; for 1h;

upstream raw materials:

tert-butyl 4-(4-nitrobenzyl)piperidine-1-carboxylate

di-tert-butyl dicarbonate

N-trifluoroacetyl-4-(p-nitrobenzyl)piperidine

pyrographite

Downstream raw materials:

1-tert-butoxycarbonyl-4-[4-(1H-tetrazol-1-yl)benzyl]piperidine

1-tert-Butoxycarbonyl-4-[4-(methylsulfonyl)aminobenzyl]piperidine

tert-butyl 4-(4-morpholin-4-ylbenzyl)piperidine-1-carboxylate

Refernces

• 1、 -. "As inhibitor and dichloropyridazine NAMPT polypyridine deriv.". Paragraph 0892. . Retrieved 2017/04/03.
• 2、 -. "NAMPT INHIBITORS". Page/Page column 225. . Retrieved 2013/12/03.