Pentanoic acid, 2-propyl-, phenyl ester

Base Information

• Chemical Name: Pentanoic acid, 2-propyl-, phenyl ester
• CAS No.: 22179-54-0
• Molecular Formula: C14H20O2
• Molecular Weight: 220.312
• Mol file: 22179-54-0.mol

Synonyms:

Chemical Property of Pentanoic acid, 2-propyl-, phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 2-propyl-, phenyl ester

There total 3 articles about Pentanoic acid, 2-propyl-, phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-iodoheptane (31294-93-6) + diphenylmethylsilanecarboxylic acid (18414-58-9) + sodium phenoxide (139-02-6) → Di-n-propylessigsaeure-phenylester (22179-54-0)

Guidance literature:

With potassium fluoride; propyl cyanide; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; (2-morpholino-N-(quinolin-8-yl)acetamido)nickel(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c09170

Reference yield:

C16H19NO4 (2387417-86-7) → Di-n-propylessigsaeure-phenylester (22179-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; lithium iodide / acetone / 20 °C / Sealed tube; Microwave irradiation

2: triethylamine; (2-morpholino-N-(quinolin-8-yl)acetamido)nickel(II) chloride; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; potassium fluoride; propyl cyanide / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere; Sealed tube; Irradiation

With potassium fluoride; propyl cyanide; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; (2-morpholino-N-(quinolin-8-yl)acetamido)nickel(II) chloride; triethylamine; triphenylphosphine; lithium iodide; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jacs.1c09170

Reference yield:

valproic acid (99-66-1) → Di-n-propylessigsaeure-phenylester (22179-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16 h / 0 - 20 °C

2: triphenylphosphine; lithium iodide / acetone / 20 °C / Sealed tube; Microwave irradiation

3: triethylamine; (2-morpholino-N-(quinolin-8-yl)acetamido)nickel(II) chloride; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; potassium fluoride; propyl cyanide / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere; Sealed tube; Irradiation

With dmap; potassium fluoride; propyl cyanide; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; (2-morpholino-N-(quinolin-8-yl)acetamido)nickel(II) chloride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; lithium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jacs.1c09170

upstream raw materials:

valproic acid

C₁₆H₁₉NO₄

4-iodoheptane

diphenylmethylsilanecarboxylic acid

Downstream raw materials:

1-(4-hydroxyphenyl)-2-propyl-1-pentanone

Refernces