1-(Diphenylphosphoryl)piperidine

Base Information

• Chemical Name: 1-(Diphenylphosphoryl)piperidine
• CAS No.: 6230-68-8
• Molecular Formula: C17H20 N O P
• Molecular Weight: 285.326
• NSC Number: 202994
• DSSTox Substance ID: DTXSID50308301
• Nikkaji Number: J832.038A
• Wikidata: Q82056100
• ChEMBL ID: CHEMBL1495865
• Mol file: 6230-68-8.mol

Synonyms:6230-68-8;NSC202994;Oprea1_235537;MLS000069268;1-(diphenylphosphoryl)piperidine;CHEMBL1495865;SCHEMBL14420676;DTXSID50308301;HMS2155L17;HMS3308D09;NSC-202994;NCGC00018758-01;NCGC00018758-02;SMR000040616

Chemical Property of 1-(Diphenylphosphoryl)piperidine

Chemical Property:

• Vapor Pressure: 3.6E-07mmHg at 25°C
• Boiling Point: 417.2°C at 760 mmHg
• Flash Point: 206.1°C
• Density: 1.16g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 285.128251259
• Heavy Atom Count: 20
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(Diphenylphosphoryl)piperidine

There total 15 articles about 1-(Diphenylphosphoryl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-benzyloxypiperidine (46346-67-2) + Diphenylphosphine oxide (4559-70-0) → diphenyl(piperidin-1-yl)phosphine oxide (6230-68-8)

Guidance literature:

With potassium carbonate; In tert-Amyl alcohol; at 105 ℃; for 8h;

DOI:10.1021/acs.orglett.5b03056

Reference yield: 84.0%

piperidine (110-89-4) + Diphenylphosphinic chloride (1499-21-4) → diphenyl(piperidin-1-yl)phosphine oxide (6230-68-8)

Guidance literature:

piperidine; Diphenylphosphinic chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

With dihydrogen peroxide; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201708440

Reference yield: 75.0%

piperidine (110-89-4) + Diphenylphosphine oxide (4559-70-0) → diphenyl(piperidin-1-yl)phosphine oxide (6230-68-8)

Guidance literature:

With potassium iodide; In ethanol; at 20 ℃; for 4h; Electrolysis;

DOI:10.1039/c7gc01989k

upstream raw materials:

piperidine

4-nitrophenyl diphenylphosphinate

Diphenylphosphinic chloride

3-acetylphenyl diphenylphosphinate