4-(4-Methoxyphenyl)butyraMide

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)butyraMide
• CAS No.: 2222-15-3
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2924299090
• Mol file: 2222-15-3.mol

Synonyms:

Chemical Property of 4-(4-Methoxyphenyl)butyraMide

Chemical Property:

• Melting Point: 119℃
• PSA: 53.31000
• LogP: 2.65290

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-methoxyphenyl)butanamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methoxyphenyl)butyraMide

There total 8 articles about 4-(4-Methoxyphenyl)butyraMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(4-Methoxyphenyl)butyric acid (4521-28-2) → 4-(4-Methoxyphenyl)-butyramide (2222-15-3)

Guidance literature:

4-(4-Methoxyphenyl)butyric acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 - -10 ℃; for 0.5h;

With ammonia; In tetrahydrofuran; methanol;

DOI:10.1021/jm051134w

Reference yield: 97.0%

4-(4-Methoxyphenyl)butyric acid (4521-28-2) + isobutyl chloroformate (543-27-1) → 4-(4-Methoxyphenyl)-butyramide (2222-15-3)

Guidance literature:

With 4-methyl-morpholine; sodium chloride; ammonia; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield: 57.0%

ammonium hydroxide (1336-21-6) + 4-(4-Methoxyphenyl)butyric acid (4521-28-2) → 4-(4-Methoxyphenyl)-butyramide (2222-15-3)

Guidance literature:

With thionyl chloride; In chloroform; toluene;

upstream raw materials:

4-(4-methoxyphenyl) butanoyl chloride

4-(4-Methoxyphenyl)butyric acid

ammonium hydroxide

isobutyl chloroformate

Downstream raw materials:

N-[4-(4-Methoxy-phenyl)-butyl)-acetamid

{4-[4-(2-tert-Butoxycarbonylaminoethoxy)phenyl]butyl}carbamic acid benzyl ester

4-[4-(1,4,7,10,13-pentoxatetradec-1-yl)phenyl]-N-benzyloxycarbonylbutylamine

4-[4-(1,4,7,10,13-pentoxatetradec-1-yl)phenyl]butylamine

Refernces

• 1、 Xu, Changliang,Bai, Xiaoguang,Xu, Jian,Ren, Jinfeng,Xing, Yun,Li, Ziqiang,Wang, Juxian,Shi, Jingjing,Yu, Liyan,Wang, Yucheng. "Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study". . p. 4763 - 4775. Retrieved 2017/02/05.
• 2、 -. "SODIUM CHANNEL BLOCKERS". . . Retrieved 2016/01/21.