1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE

Base Information

• Chemical Name: 1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE
• CAS No.: 223418-72-2
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• Hs Code.: 2932999099
• Mol file: 223418-72-2.mol

Synonyms:2-(3-bromo-4-methoxy-phenyl)-[1,3]dioxolane;1,3-Dioxolane,2-(3-bromo-4-methoxyphenyl);2-(3-bromo-4-methoxyphenyl)-1,3-10 dioxolane;1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE;

Chemical Property of 1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE

Chemical Property:

• Vapor Pressure: 0.000538mmHg at 25°C
• Boiling Point: 322.1oC at 760 mmHg
• Flash Point: 130.3oC
• PSA: 27.69000
• Density: 1.479g/cm3
• LogP: 2.50310

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-5-(1,3-dioxolan-2-yl)-2-methoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE

There total 4 articles about 1-BROMO-5-(1,3-DIOXOLAN-2-YL)-2-METHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-bromo-4-methoxybenzylaldehyde (34841-06-0) + ethylene glycol (107-21-1) → 2-(3-bromo-4-methoxyphenyl)-1,3-dioxolane (223418-72-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 24h; Heating; Dean-Stark; Inert atmosphere;

DOI:10.1002/cjoc.202000051

Reference yield: 91.0%

2-bromo-4-(1,3-dioxolan-2-yl)phenol (162271-15-0) + dimethyl sulfate (77-78-1) → 2-(3-bromo-4-methoxyphenyl)-1,3-dioxolane (223418-72-2)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1021/jm070109i

Reference yield:

3-bromo-4-methoxybenzylaldehyde (34841-06-0) + toluene-4-sulfonic acid (104-15-4) → 2-(3-bromo-4-methoxyphenyl)-1,3-dioxolane (223418-72-2)

Guidance literature:

In water; ethylene glycol; toluene;

upstream raw materials:

3-bromo-4-methoxybenzylaldehyde

ethylene glycol

2-bromo-4-(1,3-dioxolan-2-yl)phenol

dimethyl sulfate

Downstream raw materials:

4-Methoxy-3-(γ,γ-dimethylallyl)benzaldehyde

3-bromo-4-methoxybenzylaldehyde

2-(hydroxyethyl)triphenylphosphonium bromide

Refernces

• 1、 Li, Zhong-Yuan,Lakmal, Hetti Handi Chaminda,Qian, Xiaolin,Zhu, Zhenyu,Donnadieu, Bruno,McClain, Sarah J.,Xu, Xue,Cui, Xin. "Ruthenium-catalyzed enantioselective C-H functionalization: A practical access to optically active indoline derivatives". supporting information. p. 15730 - 15736. Retrieved 2019/10/11.
• 2、 Maiti, Arup,Cuendet, Muriel,Croy, Vicki L.,Endringer, Denise C.,Pezzuto, John M.,Cushman, Mark. "Synthesis and biological evaluation of (±)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer". . p. 2799 - 2806. Retrieved 2008/02/06.