Morpholine, 4-(4-ethenylphenyl)-

Base Information

• Chemical Name: Morpholine, 4-(4-ethenylphenyl)-
• CAS No.: 223556-23-8
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol file: 223556-23-8.mol

Synonyms:

Chemical Property of Morpholine, 4-(4-ethenylphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholine, 4-(4-ethenylphenyl)-

There total 7 articles about Morpholine, 4-(4-ethenylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + 4-vinylbenzyl chloride (1073-67-2,24991-47-7) → 4-(4-ethenylphenyl)-morpholine (223556-23-8)

Guidance literature:

With C₃₆H₄₅Cl₂N₃OPd; potassium tert-butylate; In 1,4-dioxane; at 90 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1021/om401028d

Reference yield: 77.0%

morpholine (110-91-8,99108-56-2) + 1-bromo-4-ethenyl-benzene (2039-82-9) → 4-(4-ethenylphenyl)-morpholine (223556-23-8)

Guidance literature:

With palladium diacetate; sodium butanolate; johnphos; In toluene; at 80 ℃; for 12h;

DOI:10.1016/j.bmc.2012.08.023

Reference yield: 76.0%

4-(4-morpholinyl)benzaldehyde (1204-86-0) + Methyltriphenylphosphonium bromide (1779-49-3) → 4-(4-ethenylphenyl)-morpholine (223556-23-8)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

4-(4-morpholinyl)benzaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jacs.1c00884

upstream raw materials:

morpholine

4-vinylbenzyl chloride

4-iodostyrene

1-bromo-4-ethenyl-benzene

Downstream raw materials:

1-(4-morpholinophenyl)-2-(phenylsilyl)ethane